Gitelman综合征伴胰岛素抵抗1例

Gitelman syndrome with insulin resistance:One case report

本文对1例Gitelman综合征(GS)伴IR患者进行报道。患者女,27岁,以低血钾(2.62mmol/L)、低血镁(0.33mmol/L)、代谢性碱中毒(HCO-327.7mmol/L)、低尿钙(1.25mmol/24h)、肾素及醛固酮增高、BP正常为主要特点。血糖正常,存在IR、Ins高峰后移、胰岛素曲线下面积(AUCi)为388.6,经补钾、补镁治疗效果好。故临床低血钾、低血镁患者,应注意鉴别排除GS。

One case of GS patient with insulin resistance was reported.The female patient aged 27 years was diagnosed as Gitelman syndrome by the typical biochemical pictures including renal wasting hypokalemia（2.62 mmol/L）,hypomagnesemia（0.33 mmol/L）,metabolic alkalosis（HCO3—27.7 mmol/L）,hypocalciuria（1.25 mmol/24 h）,high reninemic and aldosteronism and normal blood pressure.The patients showed a normal range glucose and a delay of insulin secretion peak of 120 min after a glucose load. The insulin area under curve（AUCI）was 388.6.O ral potassium and magnesium supplementation were efficacious,so GS should be considered in the differential diagnosis for the patient with hypokalemia and hypomagnesemia.