头孢噻呋钠混悬注射液在鹅体内的药代动力学

Pharmacokinetics of ceftiofur sodium suspended injection in geese

健康四川白鹅20只,随机分为A、B两组,A组单剂量静注头孢噻呋钠无菌粉针,B组单剂量肌注头孢噻呋钠混悬注射液,均按2.2mg·kg-1。用高效液相色谱法测定血浆中的药物浓度,3p97药代动力学程序软件处理药时数据。结果显示,A组药-时数据符合二室开放模型(W=1/C2);主要药代动力学参数:t1/2α0.112h,t1/2β2.711h,CL 0.234L·kg-1·h-1,V 0.064L·kg-1,AUC 9.400mg·h·L-1。B组药-时数据也符合二室开放模型(W=1/C2);主要药代动力学参数:t1/2α0.546h,t1/2β22.737h,Cmax1.252 mg·L-1,Tmax0.484h,V 1.885L·kg-1,AUC8.792mg·h·L-1。结果表明,头孢噻呋钠混悬注射液在鹅体内分布广泛,生物利用度高,且具有长效缓释作用。

Twenty healthy Siehuan white geese were allocated into two groups of 10 geese each. The geese in group A were administrated of ceftiofur sodium powder injections （2.2 mg/kg） by intra venous injection. The geese in group B were intramuscularly injected with ceftiofur sodium suspen ded injection （2. 2 mg/kg）. The plasma concentration of ceftiofur sodium was determined by HPLC. Pharmacokineties parameters were calculated by 3p97 computer program. Concentration time data for group A were best described by a two-compartment open model（W= 1/C2） and main parameters were as follows： tl/2o 0. 112 h,b/2o 2. 711 h,CL 0. 234 L. kg-1 . h-1 ,V 0. 064 L . kg 1 , AUC 9. 400 mg . h . L-1data of group B were also charactered by a two-compartment open mod- el （W=I/C2） and main parameters were as followsThese results showed that ceftio- fur sodium suspended injection had a wide body distribution, a high rate of bioavailability and a long half-time in Sichuan white geese by intramuscular injection.