伊维菌素聚酯酸酐微球的制备

Preparation of ivermectin polyester anhydride microsphere

将2种聚酯酸酐(P(SA∶RA 20∶80),P(SA∶RA 30∶70))分别与伊维菌素溶于三氯甲烷中作为有机相,以聚乙烯醇水溶液为水相,用乳化溶剂挥发法制备出2种伊维菌素聚酯酸酐微球。采用光学显微镜考察所制备微球的形态及粒径,紫外分光光度法测定载药量和包封率。结果显示,制备出的P(SA∶RA 30∶70)/IVM微球的平均粒径为(72.240±24.747)μm,载药量为19.67%,包封率为87.70%。P(SA∶RA 20∶80)/IVM微球的平均粒径为(64.18±26.14)μm,载药量为17.72%,包封率为87.27%。这表明采用乳化溶剂挥发法成功制备出2种伊维菌素聚酯酸酐微球。

Microspheres loading ivermectin （IVM） were prepared by emulsion method （O/W） based on solvent evaporation. The two kinds of P（SA ： RA） with SA/RA ratios of 20 - 80 and 30 = 70 were selected as zing agent. The surface croscopy, encapsulation microsphere matrix. Polyinyl acetate （PVA） was used as emulsion stabili morphology and particle size of microspheres was examined by optical mi and drug loa showed that the volume average size 24. 747） μm, drug loading was 19.67 average size of IVM/P（SA ： RA 20 was 17.72% hydride ding was deter of IVM/P（SA and the enca ： 80） microsph mined by UV s ： RA 30 ： 70） psulation efficie eres was （64. 1 pectrophotometry. The result microspheres was （72. 240 ncy was 87.70%. The volume 8±26. 14）μm, drug loading and the encapsulation efficiency was 87. 27%. So ivermectin （IVM） polyester an- ospheres were prepared by emulsified solvent evaporation.