丁二磺酸腺苷蛋氨酸与头孢哌酮舒巴坦配伍禁忌原因分析

Analysis of Imcompatibility between Ademetionine 1,4-butanedisulfonate and Cefoperazone/Sulbactam

目的探讨丁二磺酸腺苷蛋氨酸与头孢哌酮舒巴坦之间是否存在配伍禁忌,研究其发生白色絮状物的原因。方法采用对照试验,观察两药分别与酸性和碱性溶液混合后的外观变化,两药相互混合后及加入酸性和碱性溶液后的外观变化。结果两药正常配制条件下未出现肉眼可见理化反应,而加入酸性物质后,头孢哌酮舒巴坦立即析出白色沉淀,该沉淀可碱化复溶。结论正常配制下两药无沉淀产生,输液管中白色絮状物是由于未使用专用溶剂溶解丁二磺酸腺苷蛋氨酸,导致酸性条件下头孢哌酮析出沉淀,正确配制使用两药可能并无配伍禁忌。

Objective To investigate whether ademetionine 1,4-butanedisnlfonate and cefoperazone/sulbactam is imcompatible, and research how the white floccule emerged. Methods By controlled trial, apperance change was observed after combining each medicine with acid solution and alkaline solution, and apperance change was observed after combining the mixed liquid of two medicines with acid solution and alkaline solution. Results No evident apperance change was observed by normal dispensing, cefoperazone/sulbactam solution immediately generated white precipitate after adding acid solution, and the white precipitate could be dissolved in alkaline solution. Conclusion There was no precipitate after mixing the two medicines by normal dispensing, the reason of white precipitate was to dissolve transmeti] incorrectly. The two medicines may be compatible by correct dispensing.