摘要
目的 观察比较外源性微量去甲肾上腺素预处理及经典缺血预处理对在体大鼠缺血 /再灌注心脏损伤的保护效应。方法 将实验动物分为假手术组、缺血 /再灌注组、经典缺血预处理和去甲肾上腺素预处理等 4组。再灌结束后 ,分别测定心功能、心肌丙二醛含量 ,观察心肌超微结构、过氧化氢酶损伤性反应。结果 经典缺血预处理和去甲肾上腺素预处理均能改善心功能、保护心肌超微结构、保护心肌过氧化氢酶活性。结论 外源性去甲肾上腺素预处理是一种无明显创伤性的对缺血 /再灌注大鼠心脏具保护作用的预处理方法 ,能模拟经典缺血预处理心脏保护效应。
AIM To compare the protective effects of norepinephrine preconditioning(NEPC)and ischemic preconditioning(IPC)on myocardial ischemic/reperfused injury in rats in vivo . METHODS Rats were divided into control, ischemia/ reperfusion, classic IPC and NEPC groups. After 20 min reperfusion, several indexes including cardiac function indexes, MDA were tested, the myocardial ultrastr ucture and the injury reaction of catalase observed. RESULTS Both IPC and NEPC could protect myocardial ultra structure, ameliorate left heart function, decrease cardiac MDA content and protect the activity of catalase. CONCLUSION Extra micro norepinephrine preconditioning as a non injury method can mimic the protective effects of classic IPC and shows its clinical values.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2000年第6期699-702,共4页
Chinese Pharmacological Bulletin
基金
湖北省自然科学基金资助课题.No95J31
