三硝基甲苯作业工人和慢性乙型肝炎患者血清磷酸化酶a活性的变化

The activity changes of serum phosphorylase A in the workers exposed to trinitrotoluene and in the patients suffering from chronic hepatitis B

目的 探讨血清磷酸化酶a活性对评价TNT早期肝损伤的意义。方法 测定TNT接触组、慢性乙型肝炎患者和慢性HBsAg携带组血清磷酸化酶a活性。结果 TNT生产车间空气中TNT浓度均超过国家最高容许浓度 (MAC =1mg/m3) ,工人皮肤污染较严重。TNT接触组和慢性乙型肝炎患者血清磷酸化酶a活性与对照组比较无差异。结论 推测接触组血清磷酸化酶a活性的升高可能与TNT所致肝损伤有一定关系。如果TNT作业工人乙型肝炎病毒血清学标志为阴性 ,建议用其血清磷酸化酶a活性升高作为评价TNT早期肝损伤的指标。

Objective To study the changes of serum phosphorylase A activities in evaluating early liver damage induced by TNT.Methods The phosphorylase A activities of the TNT exposed workers group, of the patients suffering from chronic hepatitis B and of the control group were determined.Results The average TNT concentrations in the air of workshop were beyond the national maximum allowable concentration (MAC=1 mg/m 3) and the skin of TNT exposed workers were seriously contaminated with TNT. The activities of phosphorylase A in serum of both the TNT exposed worker group and the patient group suffering from chronic hepatitis B were higher than those in the control group; the activities of serum phosphorylase A of the chronic HBsAg carries group were close to the level of those in the control group.Conclusion It seemed that the increase of serum phosphorylase A activities related with liver damage. If the marker hepatitis B virus in the serum of TNT exposed workers was negative, it was suggested that the increase of serum phosphorylase A activities in TNT exposed workers might act as an index for detecting early liver damage induced by TNT.