加斯清联合针灸治疗老年餐后不适综合征的疗效观察

Clinical Observation of Gasmotin Combined with Acupuncture in Treatment of Postprandial Distress Syndrome in the Elderly

目的:探讨加斯清联合针灸治疗老年餐后不适综合征的临床疗效,旨在为临床治疗本病提供基础依据。方法:选取2011年10月—2012年10月期间就诊于本院的老年餐后不适综合征患者90例进行研究并按数字表法随机分为3组,每组30例。其中,单纯促动力组采用加斯清口服治疗;针灸组采用针灸取穴治疗;而针药并用组则采用加斯清联合针灸进行治疗。观察3组患者的各症状积分、胃排空时间以及胃动素水平的改善情况,比较不同试餐时间下的近端胃容积变化,评价3种方法的临床疗效和不良反应发生率。结果:治疗后,针药并用组的各症状积分、胃排空时间以及胃动素水平的改善情况明显优于其他两组;试餐后15、20、30、40、60 min,近端胃容积显著小于其他两组(P<0.05),而试餐后5、10 min无明显差异(P>0.05);并且,针药并用组的治疗总有效率为96.67%,明显高于其他两组的76.67%、80.00%,数据分析发现其具有显著性差异(P<0.05),而3组的不良反应率分别为13.33%、10.00%、13.33%,无明显差异(P>0.05)。结论:加斯清联合针灸应用于老年餐后不适综合征的治疗上,其疗效确切,安全性高,值得在临床上推广应用。

Objective ： To explore the clinical efficacy of Gasmotin combined with acupuncture for the treatment of post- prandial distress syndrome in the elderly which aims to provide a basis for clinical treatment. Methods：90 elderly patients of postprandial distress syndrome during October 2011 to October 2012 were selected. Among them, the simple prokinetic group were treated with Gasmotin orally. The acupuncture group were treated with acupuncture while the combined group were treated with Gasmotin combined with acupuncture. The improved situation of symptom scores,gastric emptying time and motilin levels were observed. The volume change from different test meal times was compared under the proximal stomach. The efficacy and adverse reactions of three groups were evaluated. Results ： After treatment,the improvement of combined group for symptom scores, gastric emptying time and motilin levels were better than those of the other two groups. The proximal stomach volume from the test meal time of 15,20,30,40,60 min were significantly smaller than that of the other two groups （P 〈 0.05）. But the test meal time of 5,10 rain had no significant difference （P 〉 0.05）. What＇ s more, the total effective rate of the combined group was 96.67%, significantly higher than 76.67% and 80.00% of the other two groups and there was significant difference （ P 〈 0.05 ）. And the adverse reaction rates of the three groups were 13.33%, 10.00% and 13.33% with significant difference （ P 〉 0, 05 ）. Conclusions ： The clinical efficacy of Gasmotin combined with acupuncture for the treatment of postprandial distress syndrome in the elderly is significant and safe. It is worthy of application in clinical practice.