苯那普利对高血压病患者血浆一氧化氮、内皮素浓度变化影响的研究

INFLUENCE OF BENAZEPRIL ON NITRIC OXIDE AND ENDOTHELIN SERUM CONCENTRATIONS IN PATIENTS WITH ESSENTIAL HYPERTENSION

目的 :了解高血压患者血清一氧化氮 (NO)、内皮素 (ET)的变化以及苯那普利对其影响。方法 :应用光比色法和放射免疫技术测定 5 0例高血压患者和 2 0例健康体检者血清NO、ET的浓度 ,并给高血压患者以苯那普利治疗 12周后复测上述指标。结果 :高血压组NO、ET分别是 :2 6 .48± 13.12umol/L ,12 5 .4± 39.6pg/ml其NO明显低于对照组 (P <0 .0 5 ) ,ET明显高于对照组 (P <0 .0 1) ;苯那普利治疗 12周后 ,高血压组NO、ET分别为 :40±7.8umol/L ,5 7± 10 .3pg/ml,与治疗前相比差异显著 (P <0 .0 1)。结论 :血清NO、ET水平与血压升高密切相关 ,血管紧张素转换酶抑制剂———苯那普利在有效控制血压的同时明显升高NO浓度 。

Objective: To explore the role of the serum concentrations of nitric oxide.(NO) endothelin(ET) in hypertensives and its change after benazepril treatment, Methods: Serum contents of NO.ET were measured by and radiommanossay(RIA) in 25 patients with essential hypertension (EH) and 20 healthy individuals as control, EH patients were treated with benazepril for 12 weeks, Results: Serum contents of NO.ET in EH were 26.48±13.12 mol/L 125.439.68pg/ml respectively, ET significantly higher than that in normal individuals (57±10.3pg/ml), NO significantly lower than that in normal individuals(40±7.8 mol/L), after 12 week of benazepril treatment, the levels of ET in EH decreased evidently with the reduction of blood pressure, the levels of NO in EH rise evidently with the reduction of blood pressure.Conclusio: it is suggested that serum contents of NO.ET are closely related with rise of blood pressure Benazepril reduces the serum contents of ET and rise the serun contents of NO when the blood pressure is effectively controlled.Key words Hypertension; NO; ET; Benazeprilf cavity of uterus with ultrasonography we re carried out in the patients with blee ding duration over 15 days.Serum reprodu ctive hormone was measured by radioimmun oassay and residual tissues in the cavit y of uterus were examined by microscopy in the rest of patients.Results 257 patients with vaginal bleedi ng duration over 15 days after pharmaceu tical abortion were included in this stu dy.Remained embryonic tissues in the ute rine cavity were confirmed by pathologic al examination in 140 patients(54.47%)an d residual tissues blocking the cervical canal were observed.The modified Insler score was 6.26±1.16,and it excecded in 57 patients 48.72%.The chronic end ometritis prevalence was 24.97%(29/117) by cervical canal smear examination.The rate of bleeding stop with oral norethin drone acetate in 3 days, was 83.76%(98/1 17)and curettage was carried out in rema ined cases and residual tissues were fo un d.Conclusion Cervical ex amination should be carried out routinel y in the patients with vaginal bleeding duration over 15 days after pharmaceutic al abortion.Curettage should be immediat ely carried out in patients with cervica l canal tissues blocking.Norethindrone a cetate is an effective agent for the pat ients without residual tissues cervical canal.