广州地区自然流产夫妇染色体异常核型三十年回顾分析

Retrospective analysis of chromosome karyotype data of spontaneous abortion couples in 30 years in Guangzhou

目的探讨染色体异常对生育的影响和30年来自然流产人群中异常核型类型与分布频率的变化。方法收集1982-2011年的651对(1302例)自然流产夫妇病例的染色体核型资料,进行回顾性分析,采用外周血淋巴细胞培养-G显带方法。结果 1302例患者中一共检出染色体畸变41例(3.15%),染色体异态148例(11.37%),总的染色体异常率为14.52%。将每10年的资料进行比较,与1992-2001年相比,2002-2011年染色体畸变率有升高(P<0.05);与1982-1991年相比,1992-2001年和2002-2011年的染色体异态检出率升高(P<0.05)。结论在自然流产夫妇中,染色体异常的发生率较高,而且近年有增加趋势。

Objective ： To explore the influence of chromosome abnormality on reproduction and the change of the types and distri-bution of abnormal karyotype in spontaneous abortion couples in recent 30 years. Methods： The chromosome karyotype data from 1982 to 2011 of 651 couples （1302 cases） with spontaneous abortion history were analyzed retrospectively, using peripheral blood lympho-cyte culture-G banding method. Results： Among 1302 cases, we found chromosome aberration in 41 cases （3.15%） and chromo-some heteromorphisms in 148 cases （11.37%）, so the total chromosome abnormality rate was 14. 52%. Then we compared the data every 10 years. Compared with 1992 - 2001, the chromosome aberration rate of 2002 - 2011 increased （ P 〈 0. 05 ） ; Compared with the 1982 - 1991, chromosome anomaly detection rates of 1992 -2001 and 2002 -2011 were higher （P 〈 0. 05）. Conclusion： In the population with spontaneous abortion, chromosome abnormality rate is high and has increased in recent years.