中西医对COPD肺血管重构的研究进展

Progress of Chinese and Western Medicine in COPD Pulmonary Vascular Remodeling

目的:探讨中西医对慢性阻塞性肺疾病肺血管重塑的研究进展。方法:总结归纳分析近年来的相关文献资料。结果:吸烟和炎症可能是COPD早期即出现肺血管重构的始动因素,而缺氧又加快了重塑的进程。内皮素-1、转化生长因子-β、血管内皮细胞生长因子等多种细胞因子参与并影响血管重塑的发生。中医药在改善和逆转肺血管重构方面可起到一定的治疗作用。结论:通过进一步对COPD血管重塑相关影响因素及细胞因子的表达变化的研究,可以进一步认识COPD病情的发展机制。

Objective： To investigate the studies on chronic obstructive pulmonary disease＇ s puhnonary vascular remodeling treated with traditional Chinese medicine and western medicine. Methods： The relevant literature in recent years was summed up, summarized and analyzed. Results： Smoking and inflammation may be the initial factor COPD appeares in the early stage and hypoxia also accelerate the remodeling process. ET-I, TGF-β, VEGF and other cytokines were involved and affected the vascular remodeling. Conclusion： Understanding the change of expression of factors and cytokines related effects of COPD vascular remodeling and study on the development mechanism of COPD disease.