硒对氟致肾损害的影响

Effects of Selenium on Fluoride-induced Renal Injury

给ＳＤ大鼠饮用含氟、硒、及氟加硒的水溶液８周，观察硒对氟致肾损害的影响。结果表明：氟可使肾脏脂质过氧化物含量明显增加，肾近曲小管上皮细胞变性、坏死，线粒体数目增多，线粒体嵴减少，基底膜局部增厚，并可使肾近曲小管上皮细胞的琥珀酸脱氢酶（ＳＤＨ）和碱性磷酸酶（ＡＬＰ）活性明显降低，乳酸脱氢酶（ＬＤＨ）和酸性磷酸酶（ＡＣＰ）活性明显增高。补硒后则可促进肾脏的氟排泄，降低肾脏脂质过氧化物含量，肾脏的组织病理学和超微结构改变明显减轻，ＳＤＨ活性增加，ＡＣＰ活性降低。结果提示，硒对氟导致的肾损害具有明显的拮抗作用。

In order to observe the effects of selenium on fluoride-induced renal injury of rats, the weanling SD rats were administered to fluoride, selenite, as well as fluoride plus selenite in drinking water for 8 weeks. The results showed that fluoride could significantly increase the contents of renal lipid peroxides and result in degeneration and necrosis of epithelia of renal proximal convoluted tubules. Fluoride could induce an increase of mitochondria and a decrease of mitochondrial cristae, locally thickening of basement membrane, markedly de- crease the activities of succinate dehydrogenase (SDH) and alkaline phosphatase (ALP), but elevate the activi- ties of lactate dehydrogenase (LDH) and acid phosphatase (ACP) in epithelia of renal proximal convoluted tubules. Selenite supplement in drinking water could accelerate the renal excretion of fluoride from the body, decrease the contents of lipid peroxides in kidney, and the renal changes in histopathology and ultrastructure were significantly alleviated, increase activities of SKH and decrease activities of ACP. It was suggested that se- lenium possessed the obvious antagonistical effect on the renal injury induced by fluoride.