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肿瘤微血管密度和血管内皮生长因子的表达与胃癌病理及临床分期研究 被引量:1

Studies on the Relationship between Microvessel Density and Expression of Vascular Endothelial Cell Growth Factor and Pathological Types and Clinical Stages in Gastric Carcinoma
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摘要 为研究肿瘤微血管密度(MVD)和肿瘤血管内皮生长因子(VEGF)的表达水平与胃癌的病理及临床分期间的关系。应用抗人Ⅷ因子相关抗原抗体,抗VEGF单克隆抗体,采用ABC免疫组化法,分别检测45例胃癌组织中MVD和VEGF的表达水平。结果发现,胃癌组织中MVD平均值为31.4±14.3,VEGF表达阳性率为53.3%(24/45),VEGF表达阳性者 MVD值显著高于阴性者(P<0.05);MVD值和 VEGF表达在不同的Borrmann分型及TNM分期中各不相同,并随着疾病的分期而增加(P<0.01)。提示:胃癌MVD值和VEGF的表达密切相关,并与胃癌的病理及临床分期相联系,两者均可作为反映胃癌生物学行为的有用指标。 The relationship between the microvessel density (MVD), the expression of vascular endothelial cell growth factor (VEGF) and the pathological types and clinical stages in gastric cancers was studied. The MVD and the expression of VEGF in the samples of gastric cancers were assayed by using immunohistochemical methods of SABC with human factor Ⅷ related antibody, the VEGF monocolonal antibody. The mean value of MVD and the positive rate of VEGF expression in gastric cancer were 31.4 ±14.3 and 53.3% (24/45) respec- tively, and the value of MVD in those with positive VEGF expression was markedly higher than that in those with negative VEGF expression (P<0.05). The value of MVD and the positive rate of VEGF expression were varied in different Borrmann types and TNM stages and were raised with the types and stages of gastric cancer improved (P<0.01 ). It was suggested that the MVD value in gastric carcinoma was closely related with the expression of VEGF and associated with the pathological types and clinical stages. Both of them could be used as the useful indexes reflecting the biological behavior of gastric carcinoma.
出处 《同济医科大学学报》 CSCD 2000年第6期534-536,共3页 Acta Universitatis Medicinae Tongji
基金 卫生部临床学科重点资助项目(67168)
关键词 肿瘤微血管密度 血管内皮生长因子 胃癌 病理 microvessel density vascular endothelial growth factor gastric carcinoma Borrmann type TNM stage
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  • 1[1]Folkman J. The tale of angiogenesis in tumor growth. Semin Cancer Biol, 1992, 3:65
  • 2[2]Gasparinni G, Weidner N, Beiilacqua P et al. Tumor microvessel density, P53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic marker in nodenegative breast carcinoma. J Clin Oncol, 1994, 12:454
  • 3[3]Maed K, Chung Y S,Takatsuka S et al.Tumor angiogenesis as a predicator of recurrence in gastric carcinoma. J Clin Oncol, 1995, 13:477
  • 4[4]Weidner N, Folkman J, Pozza F et al. Tumor angiogenesis: a new significant and independent prognostic indicator in early state breast carcinoma. J Natl Cancer Inst, 1992, 84:1875
  • 5[5]Leung D W, Cachianes G, Kuang W J et al. Vascular endothelial growth factor is a secreated angiogenic mitogen. Science, 1989, 246:1306
  • 6[6]Hanahan D, Folkman J. Patterns and emerging mechanism of the angiogenic switch during tumorgenesis. Cell, 1996, 86:353
  • 7[7]Tanigawa N, Amaya H, Matsumura M et al. Extent of tumor vascularization correlates with prognosis and hematoogenous metastasis in gastric carcinoma. Cancer Res, 1996, 56:2671
  • 8[8]Takahashi Y, Kitadai Y, Bucana C D et al. Expression of vascular endothelial. Growth factor and and receptor, KDR, correlate with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res, 1995, 55:3964
  • 9[9]Van Hoef M C H M, Knool M F, Dhesi S S et al. Assessment in lymph node negative invasive breast cancer. Eur J Cancer, 1993, 29A: 1141

同被引文献15

  • 1刘迪群,吴成秋,刘景生,雷丁洪.环氧化酶-2、血管内皮生长因子、微血管密度与胃癌侵袭转移的相关性研究[J].中国内镜杂志,2005,11(5):471-473. 被引量:3
  • 2[1]Weider N.Tumor angiogenesis:review of current applications in tumor prognostication[J].Semin Diag pathol,1993,10 (4):302-313.
  • 3[2]Folkman J.Tumor angiogensis:role in regulation of tumor growth[J].Symp Soc Dev Biol,1974,30(0):43-52.
  • 4[3]Gaspanrinni G,Weidner N,Bevilacqua P,et al.Tumor microvessel density,P53 expression,tumor size,and peritumoral lymphatic vessel invasion are relevant prognostic marker in nodenegative breast carcinoma[J].Clin Oncol,1994,12(3):454-466.
  • 5[4]Maeda K,Churg YS,TaKatsuka S,et al.Tumor angiogenesis as a predicator of recurrence in gastric carcinoma[J].Clin Oncol,1995,13(2):477-481.
  • 6[5]Folkman J.Tumor angiogenesis:therapeutic implication[J].N Engl J med,1971,285(3):1182-1186.
  • 7[6]Nagy JA,Brown LF,Senger DR,et al.Pathogenesis of ascites tumor storma generation:a critical role for leaky blood vessels and fibrin deposition[J].Biochem Biophy Acta,1989,94(7):305-324.
  • 8[7]Maeda K,Chung YS,Ogawa Y,et al.Prognostic value of vascular endothelial growth factor expression in gastric carcinoma[J].Cancer,1996,77(6):858-863.
  • 9[8]Tanigawa N,Amaya H,Matsumara,et al.Correlation between expression of vascular edothelial growth factor and tumor vascularity and patient outcome in human gastric carcinoma[J].J Clin Oncol,1997,15(6):826-832.
  • 10[9]Takahashi Y,Ellis LM,Ohta T,et al.Angiogenesis in poorly differentiated medullary carcinoma of stomach[J].Surg Today,1998,28(8):367-372.

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