瑞替普酶溶栓治疗急性ST段抬高性心肌梗死20例疗效观察

目的：观察瑞替普酶（重组人组织型纤溶酶原激酶衍生物,rPA）溶栓治疗急性ST段抬高型心肌梗死的临床疗效。方法：选取发病时间〈12小时的20例急性ST段抬高性心肌梗死患者,首次静脉推注瑞替普酶（18mg）进行溶栓,30分钟后重复1次,每次应在2~3分钟内完成。观察溶栓治疗后的再通率、胸痛缓解率,是否并发出血或过敏反应等。结果：瑞替普酶静脉溶栓治疗后再通率达到95%,未见脑、内脏等严重出血并发症和过敏反应。结论：早期瑞替普酶溶栓治疗急性ST段抬高型心肌梗死疗效显著,不良反应少。

Objective：To observe the cura-tive effect of 20 cases of reteplase（the origi- nal human recombinant tissue type fibrino-lytic enzyme kinase derivatives,rPA）throm-bolysis treat acute st-elevation myocardial infarction.Methods：To collect 20 cases of acute st-elevation myocardial Infarction pa-tients,the disease time less than 12 hours.In-travenous push note,for the first time re-teplase intravenous injection thrombolysis, repeated one time after30 minutes,each time should be completed within 2 -3 minutes. After thromholysis treatment,observe the re-canalization rate,the chest pain remission rate,whether concurrent bleeding and ana-phylactic reaction,etc.Resuhs：The recanali-zation rate after reteplase venous thrombo-lytictherapy is 95%,no brain,internal organs, such as severe bleeding complications and anaphylactic reaction.Conclusion：The cura- tive effect of reteplase early stage thrombol-ysis treat acute st-elevation myocardial in- farction is remarkable,and fewer adverse re- actions.