贝飞达对化疗后肠道菌群失调治疗作用的临床研究

目的:探讨微生态制剂贝飞达对恶性血液病患儿由于化疗导致肠道菌群失调的预防作用。方法:将62例恶性血液病患儿随机分为观察组和治疗组。前后2个周期化疗期间监测血常规,进行粪便菌群失调检查。结果:2个周期化疗后,对照组有15例出现肠道菌群失调,发生率48.4%;治疗组有8例出现肠道菌群失调,发生率25.8%,二者差异有统计学意义(P<0.05)。结论:微生态制剂贝飞达对恶性血液病患儿化疗导致的胃肠菌群失调有预防作用。

Objective：To explore the pre-ventive effect of microecologics Bei feida to the intestinal dysbacteriosis after chemo- therapy in hematological malignancies chil-dren patients.Method：62 cases of hematolog-ical malignancies children patients were randomly divided into observation group and treatment group.During the before and after two cycles of chemotherapy,monitoring rou-tine blood,fecal bacterium group of disorders check.Results：After two cycles of chemo- therapy,the control group have 15 cases with the intestinal dysbacteriosis,the incidence is 48.4% ;the treatment group have 8 cases with the intestinal dysbacteriosis,the inci-dence is 25.8% ,the difference was statisti-cally significant（P 〈0.05）.Conclusion： Therefor microecologics Bei feida have the preventive effect ofthe intestinal dysbacteri-osis after chemotherapy in hematological malignancies children patients.