鼻及副鼻窦内翻性乳头状瘤的组织学发生及p53、PCNA表达与预后的关系

Histogenesis,the Relation between Expression of p53 and PCNA and Prognosis of Inverted Papilloma of nose and Paranasal Sinuses

目的 探讨鼻内翻性乳头状瘤的组织学发生及p53、PCNA表达与预后的关系。方法 采用组织学观察、免疫组化技术对 33例鼻内翻性乳头状瘤的组织学成分及p53、PCNA进行定性、定量研究。结果 鼻内翻性乳头状瘤中存在假复层纤毛柱状上皮、移行上皮、鳞状上皮成分以及CK5&8染色阳性的瘤细胞 ;p53蛋白阳性表达、PCNA指数与不典型增生及癌变显著相关 ,与复发无关 ;p53与PCNA反应强度平行。结论 内翻性乳头状瘤是由鼻粘膜基底层细胞增殖而来的 ;p53阳性表达及PCNA指数高者预后差。

To explore histogenesis and the relation between expression of p53 and proliferating cell nuclear antigen(PCNA)and prognosis of inverted papilloma of nose and paranasal sinuses.Methods Histologic observation and immunohistochemistry were used to study the histogenic constituent and the expression of p53 and PCNA both qualitatively and quantitatively in 33 inverted papilloma.Results The neoplastic epithelia contains respiratory pseudostratified ciliated columnar、transitional and squamous epithelia and cytokeratin 5&8 immunoreactivity cells;p53 protein positive expression and PCNA LI were significantly related to both dysplasia and malignant transformation of imverted papilloma;The intensity of p53 reaction was correlated to that of PCNA.Conclusion The inverted popilloma was drived from cells of the basal layer of the nasal mucosa;The patiens with p53 protein immunoreactivity positively and high PCNALI have a poor prognosis.