非小细胞肺癌血管内皮生长因子的表达及其意义

Studies on the Expression of VEGF in Human Non-Small-Cell Lung Cancer

目的 研究血管内皮生长因子 (VEGF)在非小细胞肺癌 (NSCLC)中的表达及其临床意义。方法 应用链霉菌抗生物素蛋白—过氧化物酶 (SP)法染色技术测定 65例NSCLC组织标本的VEGF蛋白的表达水平 ,并分析其与病理类型、区域性淋巴结转移、肿瘤大小及病理分期之间的关系。结果 VEGF在NSCLC组织中表达的阳性率为 78 5% ,显著高于癌旁组织 ( 3 1% ) ;VEGF的表达与肿瘤大小有关 ,Φ≥ 5cm和 3 0≤Φ <5 0cm组的阳性率均显著高于Φ <3 0cm组 (P <0 0 5) ,但与病理类型、区域性淋巴结转移及病理分期无关 (P <0 0 5)。结论 检测VEGF的表达 ,有可能为判断NSCLC病变的发展以及评估预后提供依据。

To study the clinical significance of expression of VEGF in non-small-cell lung cancer (NSCLC).Methods By using SP immunohistochemical method with anti-VEGF multiclonal antibody,we detected the expression of VEGF in 65 cases NSCLC and studied the correlation between expression of VEGF and pathological types,lymph node metastases,the size of tumor mass and clinical stages.Results The total positive rate (78 5%)of VEGF expression in NSCLC was much higher than that(3 1%)in the nomal tissues nearby.VEGF expression was associated with the size of tumor mass ( P <0 05),but had no association with pathological types,lymph node metastases or the desease staging.Conclusion The data demonstrated that expression of VEGF might be used as an Abstract indicator of the extent of invation and the prognosis in NSCLC.