淡蓝色嵴对Barrett食管及胃黏膜肠上皮化生诊断价值的Meta分析

Meta-analysis of diagnostic value of light blue crest for detecting intestinal metaplasia in Barrett's esophageal and gastric mucosa

目的系统评价窄带成像结合放大内镜观察淡蓝色嵴对诊断Barrett食管及胃黏膜肠上皮化生的诊断价值。方法收集关于淡蓝色嵴对诊断Barrett食管及胃黏膜肠上皮化生准确性研究的文献，进行Meta分析。结果4篇文献（包含285例患者的854例标本）纳入异质性分析，以同质性较高的3篇文献，包括247例患者的626例标本进行合并分析，合并敏感度0．895（95％CI：0．861～0.923）、特异度0900（95％CI：0862～0．931）、SROC曲线下面积0.957。结论窄带成像结合放大内镜观察淡蓝色嵴对诊断胃黏膜肠E皮化生具有较高的敏感度及特异度。

Objective TO access the diagnostic value of light blue crest （LBC） observation by magnification endoscopy （NBI-ME）combined with narrow band imaging for detecting intestinal metaplasia （IM） in Barrett＇s esophageal and gastric mucosa. Methods ,6, meta-analyis was performed to evaluate the research articles on the accuracy of LBC-based diagnosis of IM. Results Heterogeneity analysis was performed in four articles including 285 patients with 854 lesions met the inclusion criteria, and there was no significant heterogeneity among three studies, including 247 patients with 626 lesions. The pooled sensitivity, specificity and SROC were 0.895 （95%Cl： 0.861N0.923）, 0.900 （95%Cl： 0.862-0.931） and 0.957 in the diagnosis of IM. Conclusion LBC observation NBI-ME combined with narrow band imaging has higher pooled sensitivity and specificity in the diagnosis of gastric IM, but more studies should be performed to access the diagnostic value of LBC for detecting intestinal metaplasia in Barrett＇s esophagus.