舟山海岛地区不同孕期妇女甲状腺激素变化趋势分析

Changes of thyroid hormones during early,middle and late gestation of pregnant women in Zhoushan city

目的了解舟山海岛地区妊娠妇女的孕期甲状腺激素变化过程。方法选取孕妇358例，检测其孕早期、孕中期、孕晚期血清甲状腺激素，并按年龄分组用一般线性模型进行对比分析。结果孕晚期TT3、TT4。、FT3含量均高于孕早期和孕中期，差异有统计学意义（P〈0.01）。24～30岁年龄组孕晚期TT3、TT4、FT3含量均高于孕早期和孕中期，差异有统计学意义（P〈0．01）。31岁以上年龄组孕早期TT4、FT4含量均低于0～23岁和24～30岁年龄组，差异有统计学意义（P〈0．05或0．01）；孕晚期TT3、TT4含量31岁以上年龄组均低于0～23岁和24～30岁年龄组，差异有统计学意义（P〈0．05或0．01），FT3、FT4含量31岁以上年龄组低于24～30岁年龄组，差异有统计学意义（P〈O．05）。结论加强对海岛地区孕妇孕晚期尤其是24～30岁育龄阶段孕晚期甲状腺激素的监测，有助干减少当地妊娠甲状腺疾病的发生。

Objective To investigate the changes of thyroid hormones during early, middle and late gestation of pregnant women in Zhoushan city. Methods Serum thyroid hormone levels were measured during early, middle and late gestation of 358 women in Zhoushan city. The results were analyzed with the General Linear Model. Results Serum levels of TT3, TT4 and TSH in late pregnant stage were significantly higher than those in early and middle stages （P〈0.01）. Serum levels of TT4 and FT4 of ≥31 age group in early gestation were significantly lower than those of ≤23 and 24 - 30 groups （P〈0.05 or 0.01）. Serum levels of TT3 and 774 of ≥ 31 group in late gestation were significantly lower than those of ≤ 23 and 24- 30 groups（P〈0.05 or 0.01）, and serum levels of FT3 and FT4 of ≥31 group were significantly lower than those of 24 - 30 group （P〈0.05）. Conclusion Monitoring serum thyroid hormone levels of pregnant women, particularly those at age of 24 to 30, would be necessary for prevention of thyroid dis- ease.