鸦胆子油乳配合全脑放疗对非小细胞肺癌脑转移效果的临床观察

The research of the brucea javanica oil emulsion combined with the whole radiotherapy in non-small cell lung cancer patients with brain metastasis

目的 比较鸦胆子油乳配合全脑放疗和单纯放疗对非小细胞肺癌脑转移的效果.方法 回顾性分析53例非小细胞肺癌脑转移患者的临床资料,其中鸦胆子油乳配合全脑放疗（治疗组）27例,单纯放疗（对照组）26例.结果 治疗组、对照组客观缓解率分别为77.8％（21/27）、69.2％（18/26）,两组差异无统计学意义（P＞0.05）.治疗组、对照组生存质量好转率分别为66.7％（18/27）、30.8％（8/26）,稳定率分别为22.2 ％（6/27）、30.8 ％（8/26）,恶化率分别为11.1％（3/27）、38.5％（10/26）,两组差异均有统计学意义（均P＜0.05）.治疗组、对照组临床症状客观有效率分别为92.6％（25/27）、69.2％（18/26）,两组差异有统计学意义（P＜0.05）.结论 鸦胆子油乳配合全脑放疗能明显改善患者临床症状,提高生存质量,对脑转移瘤放疗效果有一定提高作用.

Objective To compare the efficacy between the brucea javanica oil emulsion combined with the whole radiotherapy group （treatment group） and only radiotherapy group （control group） in non-small cell lung cancer patients with brain metastases.Methods The clinical data of 53 non-small cell lung cancer patients with brain metastasis were retrospectively reviewed,including 27 cases in treatment group and 26 cases in control group.Results The remission rates were 77.8 ％ （21/27） and 69.2 ％ （18/26） respectively in treatment group and control group.The improvement rates of Kamofsky in the treatment group and control group were 66.7 ％ （18/27） and 30.8 ％ （8/26）,the stable rates were 22.2 ％ （6/27） and 30.8 ％ （8/26）,the decrease rates were 11.1％ （3/27） and 38.5 ％ （10/26）.The remission rates of clinical sympotoms were 92.6 ％ （25/27） and 69.2 ％ （18/26） respectively in treatment group and control group.The difference of remission rate between two groups has no statistic significance （P ＞ 0.05）,while the difference of the quality of life and clinical sympotoms between two groups were significant respectively （P ＜ 0.05）.Conclusion The brucea javanica oil emulsion combined with the whole radiotherapy can relieve clinical sympotoms and improve the quality of life of patients,and may play a role on improving the effect of radiotherapy.