肺癌VEGF及PCNA的表达及其与预后的关系

The expression of VEGF and PCNA in lung cancer and the relationship with prognosis

目的:探讨肺癌血管内皮生长因子(VEGF)及增殖细胞核抗原(PCNA)的表达及其与预后的关系。方法:采用免疫组织化学方法对62例肺癌组织及50例正常肺组织VEGF及PCNA进行检测,对比两组间VEGF及PCNA的表达及其与患者预后的关系。结果:肺癌组织VEGF及PCNA阳性率分别为67.7%和72.6%,显著高于正常肺组织的14.0%和12.0%(P<0.05);肺癌VEGF阳性率与分化程度、淋巴转移、肿瘤大小及临床分期显著相关(P<0.05);PCNA阳性率与分化程度、淋巴转移及临床分期显著相关(P<0.05);VEGF及PCNA阳性肺癌患者5年生存率显著低于阴性者(P<0.05)。结论:VEGF及PCNA与肺癌的发生、进展及转移等生物学行为关系密切,可做为评估病情及预后的指标之一。

Objective： To explore the expression of VEGF and PCNA in lung cancer and the relationship with prognosis. Methods： Immunohistochemistry was used to detect VEGF and PCNA in 62 samples with lung cancer and 50 samples with normal lung tissue. The difference of VEGF and PCNA and their relationship with the prognosis of lung cancer were studied. Results：The positive rates of VEGF and PCNA were 67.7% and 72.6%, of which were much higher than those in normal lung tissue （14.0% and 12.0%, P〈0.05） ;The expression of VEGF closely related with differentiation, lymphatic metastasis, tumor size and clinical stage （P〉0.05） ;The expression of PCNA correlated with differentiation, lymphatic metastasis and clinical stage （P〈0.05）; The 5 year survival rates were much lower on the VEGF and PCNA positive patients （P〈0.05）. Conclusion：VEGF and PCNA closely relate with the occurrence, progress and metastasis of the lung cancer, and can be the evaluation indexes of disease and prognosis.