摘要
目的研究β1肾上腺素能受体(β1-AR)基因多态性对比索洛尔降压疗效的影响。方法 200例高血压病患者给予相同剂量比索洛尔降压治疗,同时用聚合酶链反应限制片长多态性法检测其基因型,比较不同基因型高血压患者治疗效果。结果治疗后基因型为49SG/389AA的患者静息心率、舒张压、收缩压、平均动脉压水平明显高于其他3组,差异有统计学意义(P<0.05)。基因型为49SS/389GA的患者上述指标明显低于其他3组,差异有统计学意义(P<0.05)。经过多因素非条件Logistic回归分析显示,肾上腺素受体基因型49SG/389GA是影响比索洛尔治疗高血压临床效果的危险因素。结论β1-AR基因多态性位点Ser49Gly、Gly389Arg与比索洛尔降压疗效相关。
Objective To determine the effect of β1-adrenoreceptor （β1-AR） gene polymorphism on bisoprolol treatment for pa-tients with hypertension. Methods A total of 200 patients with essential hypertension were given bisoprolol by the same dose. β1-AR genotypes with the polymerase chain reaction restriction fragment length polymorphism were used to compare the ef- ficacy with different genotypes. Results The resting heart rate, systolic pressure and diastolic pressure and mean arterial pres-sure ofgenotype 49SG/389AA were significantly higher than those in the other 3 groups, with significant difference （P 〈 0.05）. The above indicators in genotype 49SS/389GA were significantly lower than those in the other 3 groups, with significant dif-ference （P 〈 0.05）. Conclusion β1-AR gene Ser49Gly and G1y389Arg polymorphism are related to bisoprolol treatment for patients with hypertension.
出处
《中南药学》
CAS
2013年第12期896-899,共4页
Central South Pharmacy
