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马来酸罗格列酮的合成工艺改进 被引量:3

An improved synthesis of rosiglitazone maleate
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摘要 对马来酸罗格列酮的合成方法进行改进 ,5步反应总收率为 2 8 6 % Rosiglitazone maleate was synthesized through an improved method.The total yield was improved from 13 1% to 28 6%.
出处 《沈阳药科大学学报》 CAS CSCD 2001年第1期18-19,共2页 Journal of Shenyang Pharmaceutical University
关键词 抗糖尿病药 马来酸罗格列酮 合成 antidiabetic drug rosiglitazone maleate synthesis
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参考文献4

  • 1[1]Sorbera LA, Rabasseda X, Castaner J,et al. Rosiglitazone Maleate [J].Drug of the Future,1998,23(9):977-985.
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同被引文献17

  • 1张爱华,沈义鹏,丁娅.罗格列酮的合成[J].齐鲁药事,2005,24(11):685-687. 被引量:2
  • 2罗景慧.糖尿病治疗药罗格列酮[J].国外医药:合成药、生化药、制剂分册,2000,21(2):102-103.
  • 3Sorbera L A,Rabasseda X,Castaner J,et al.Rosiglitazonemaleate[J].Drug of the Further,1998,23(9):977-985.
  • 4Cantello B C C,Cawthorne M A,Cottam G P,et al.[[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinedio-nes as potent antihyperglycemic agents[J].J Med Chem,1994,37(23):3977-3985.
  • 5Cantello B C C,Cawthorne M A,Haigh D,et al.The syn-thesis of BRL 49653-A novel and potent antihyperglycemicagent[J].Bioorg Med Chem Lett,1994,4(10):1181-1184.
  • 6Fischer J,Fodor T,Lévai S,et al.Antidiabetic thiazolidine-diones and their preparation[P].WO:0144240,2001-06-21.
  • 7Vyas S K.Process for the preparation of pyridine deriva-tive[P].US:20020115866,2002-08-22.
  • 8Chmielewski M K,Marchán V,Cies'lak J,et al.Thermo-lytic carbonates for potential 5'-hydroxyl protection of de-oxyribonucleosides[J].J Org Chem,2003,68(26):10003-10012.
  • 9Ambalai M I,Chandrakant S M,Rameshkumar S K,et al.An improved process for the preparation of 4-[2-(methyl-2-pyridinylamino)ethoxy]benzaldehyde,an intermediatefor the preparation of rosiglitazone[P].EP:1905761,2008-04-02.
  • 10LI Xin,Abell C,Warrington B H,et al.Polymer-assistedsolution phase synthesis of the antihyperglycemic agentRosiglitazone[J].Org Biomol Chem,2003,1(26):4392-4395.

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