盐酸苯喹咛对失血性休克大鼠的影响

Therapeutic effects of benquinin hydrochloride on hemorrhagic shocked rats

目的 :探讨抗胆碱能药物盐酸苯喹咛对休克的治疗作用。方法 :给失血性休克模型大鼠 15只分为 3组 ,盐酸苯喹咛 1mg/kg,iv,观察给药前后不同时间血细胞灌流量、平均动脉压 (MABP)、呼吸频率与通气量等指标的变化 ,并与山莨菪碱 5mg/kg,iv进行了比较。结果 :山莨菪碱在给药后 5 min使大鼠耳廓血细胞灌流量、MABP、呼吸频率以及通气量均有短暂的降低 ,然后缓慢上升 ,与对照组相比 ,只有耳廓血细胞灌流量与 MABP明显升高 ;盐酸苯喹咛对大鼠 MABP无明显改变 ,但能迅速提高休克大鼠耳廓血细胞灌流量 ,且保持在较高水平 ,对呼吸频率与通气量也有明显提高 ,死亡时间与山莨菪碱组相当 ,均有明显延长。结论 :盐酸苯喹咛通过对微循环的调节作用以及对机体气体交换能力的提高 ,使休克状态得以改善 ,提高休克机体的生存质量。

AIM: For evaluation of the therapeutic effects of benquinin hydrochloride on hemorrhagic shocked rats. METHODS: Fifteen hemorrhangic shocked male rats were divided into 3 different groups ( n =5): saline control, anisodamine treated group and benquinin hydrochloride treated group, time courses of the changes on 4 important life indexes such as mean arterial blood pressure (MABP), respiratory rate were recorded. RESULTS: Anisodamine (5 0 mg/kg, iv) had decreases in the microvascular perfusion of the rat ear, MABP, respiratory rate and exchanged air volume of the shocked rats at 5 min when compared with the control, followed by slow increases at later time points, were observed during the experimental period. Benquinin hydrochloride (1 mg/kg, iv) had no effect on the MABP when compared with the control group, but it immediately increased the microvascular perfusion in the rat ear very significantly for the first 15 min and kept at an comparatively high level, being nearly equal to that of the treatment with anisodamine. Benquinin hydrochloride also increased the respiratory rate, exchanged air volume in the shocked rats. CONCLUSION: Although the rat viability and the death time were nearly the same between the anisodamine and benquinin hydrochloride treated groups, the results suggest that benquinin hydrochloride may have increased the life quality of the hemorrhagic shocked rats by its speedy modification of the microcirculation and its enhancement of the respiratory function.