胃癌中幽门螺杆菌感染与原癌基因c-met表达及预后研究

THE PROGNOSTIC RESEARCH AND RELATIONSHIP BETWEEN HELICOBACTER PYLORI AND EXPRESSION OF C-MET ONCOGENE IN GASTRIC CARCINOMAS

目的 研究幽门螺杆菌 (Hp)感染的胃癌 (GC)组织中c-met表达及 (Hp)感染对胃癌预后的影响。 方法 经病理证实 ,不同病变胃粘膜 145例以免疫组化检测c -met基因表达 ,以W -S法及快速尿素酶试验检测 (Hp)感染。 结果 在浅表性胃炎 (CSG)、萎缩肠化生胃炎 (CAG +IM )、异型增生 (DYS)、早期GC和进展期GC中 ,c -met基因表达率分别为2 5 5 3 % ,5 1 2 8% ,6 1 5 4% ,6 6 6 7%和 6 8 42 % ,CAG +IM、DYS、GC均显著高于CSG(P <0 0 5 )。肠型胃癌c -met阳性表达与 (Hp)感染密切相关。CAG +IM ,DYS和GC组c -met阳性表达 (Hp)感染者明显高于阴性组。 (Hp)阳性者 5年生存期显著短于 (Hp)阴性者。 结论 (Hp)感染和c-met表达与胃粘膜增殖和恶化有关 。

Aim To determine whether there is a relationship between Helicobacter pylori(Hp) and expression of c met oncogene in gastric mucosal lesions,and prognostic significance of gastric carcinomas(GC).Methods Hp and expression of c met were investigated in 145 gastric mucosal lesions by using immunohistochemistry,and Hp was examined by Warthin starry method.Results For chronic superficial gastritis (CSG),chronic atrophic gastritis and intestinal mataplasia (CAG+IM),dysplasia(DYS),early GC and advanced GC,the expression rates of c met were 25.53%,51.28%,61.54%,66.67% and 68.42% The positive rates were higher in CAG+IM,DYS and GC than in CSG(P<0.05).Expressions of c met of Hp positive were higher than Hp negative in intestinal GC(P<0.05).Expressions of c met were correlated significantly with Hp positive in CAG+IM,DYS and GC.The survival rate of patients with Hp non infection.Conclusions Hp infection and expression of c met may be associated with in proliferation and malignant transformation of gastric mucosa.Hp infection is associated with prognosis of gastric carcinoma.