摘要
Y染色体无精子症因子(azoospermia factor,AZF)区域微缺失与男性不育密切相关,是最常见的导致无精子症与严重少精子症的分子遗传病因。AZF区域包括三个遗传域AZFa区,AZFb区和AZFc区。在本文中将对AZF基因结构和功能作一综述。
AZF (azoospermia factor) microdelections, which are closely associated with male infertility, represent the most fre- quent molecular genetic causes of the azoospermia and severe oligozoospermia. The AZF regions include AZFa, AZFb and AZFc. The article reviews the gene structure and function of AZF.
出处
《中国优生与遗传杂志》
2014年第2期8-9,79,共3页
Chinese Journal of Birth Health & Heredity
关键词
无精子症因子
男性不育
生精障碍
Azoospermia factor
Male infertility
Spermatogenic impairment