体外受精-胚胎移植周期血浆总肾素及甾体激素水平对妊娠的影响

Effects of blood total renin and steroid concentrations on pregnancy in in vitro fertilization and embryo transfer.

目的 研究肾素 -血管紧张素系统及甾体激素对体外受精 -胚胎移植结局的影响。方法 用促性腺激素释放激素激动剂、促卵泡素、人绝经期促性腺激素、人绒毛膜促性腺激素方案控制下超排卵进行体外受精-胚胎移植治疗 53例不孕患者 ,在注hCG日及取卵前采集静脉血 ,测定血浆总肾素水平 ,血清雌二醇 (E2 )、孕酮(P)、睾酮 (T)水平。结果 妊娠组注hCG日血浆总肾素水平显著高于未妊娠组 (P <0 0 5) ,E2 、P显著低于后者(P <0 0 5,P <0 0 1 )。妊娠组注hCG后 36h血浆总肾素、E2 水平均低于未妊娠组 (P均 <0 0 5) ,其余参数在两组间无显著差异。结论 注hCG日血高总肾素水平 ,注hCG 36h后低总肾素水平有助于妊娠。

Objective To observe the effects of renin -angiotensin system(RAS) and steroid hormones on pregnancy in in vitro fertilization and embryo transfer(IVF-ET). Methods 53 tubal infertility women underwent IVF-ET under control of ovarian hyperstimulation with GnRHa/FSH/hMG/hCG. Plasma total renin, serum estradiol(E 2), progesterone(P) and testosterone(T) were measured on the day of injection of injection of hCG and 36h after hCG(before getting the oocytes). Results Plasma total renin level on the day of hCG in pregnant group was higher than that in nonpregnant group(P<0 05), E 2 and P lower than that in nonpregnant group(P<0 05, P<0 01). Plasma total renin and E 2 levels 36h after hCG in pregnant group were lower than that in nonpregnant group(P<0 05). There was no difference in other hormones between the two groups. [WT5”,6HZ]Conclusion The high concentration of total renin on the day of hCG injection and its low concentration 36h after hCG administration are probably conducive to pregnancy.