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COP方案联合沙利度胺治疗Castleman病合并卡波西肉瘤一例 被引量：2

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摘要 患者 男,68岁,因发现胸壁肿物10年余,肿物溃破11个月余,于2008年08月25日入院.患者自诉20世纪70年代曾患胸腺瘤,经放疗后治愈.1997年无明显诱因发现胸壁肿物,直径约2.5 cm,质稍硬,色白,无痒痛感,无渗液.当时未予重视,未行检查及治疗.2007年因肿物处皮肤擦伤导致破溃,创面渗血,触觉丧失,曾在我院治疗,予消毒换药等处理,创面缩小后出院.2008年8月患者出现溃疡范围增大,约5 cm×5 cm.胸部X线片检查示：胸骨柄骨质破坏.胸部CT示：胸骨柄骨质改变,结合病史考虑肿瘤放疗后骨髓炎双侧腋窝多发淋巴结肿大,肿瘤转移及淋巴瘤待排除.为明确诊断行右侧腋窝淋巴结活组织检查,病理改变为：滤泡增多,生发中心萎缩,滤泡外套层小淋巴成同心圆排列;毛细血管穿入滤泡中心,管型壁增厚并玻璃样变.病理诊断为：Castleman病（CD）,透明血管型.2008年10月行胸部病灶清除术、皮瓣转移术.关键词：巨淋巴结增生;肉瘤,卡波西;药物疗法。
作者 胡曦月 蓝海 古学奎
机构地区 广州中医药大学第一临床医学院 广州中医药大学第一附属医院血液科
出处 《白血病．淋巴瘤》 CAS 2013年第12期764-765,共2页 Journal of Leukemia & Lymphoma
关键词 巨淋巴结增生 肉瘤 卡波西 药物疗法 联合
分类号 R733.1 [医药卫生—肿瘤]
  • 相关文献

参考文献20

  • 1刘炜炜,葛春林,陈旭春,李建华,任玲,李璇,王坤.12例多中心型Castleman病的诊断与治疗[J].中国肿瘤临床,2010,37(20):1179-1183. 被引量：12
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二级参考文献41

  • 1张仪,李甘地,刘卫平.Castleman病的病因和发病机制研究进展[J].中华病理学杂志,2005,34(12):812-815. 被引量：55
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共引文献39

同被引文献32

  • 1秦兰.放、化疗治疗Castleman病1例的疗效观察.健康必读:下旬刊,2012,1(9):13.
  • 2Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J. Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study) : evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis, 2009,68(10):1580-1584.
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  • 8Tan TY, Pang KP, Goh HK, et al. Castleman's disease of the neck:a description of four cases on contrast-enhanced CT [ J ]. Br J Radilol, 2004, 77 ( 915 ) : 253-256.
  • 9王晓新,刘桐林,李鹏程,黄伟明.胸部局限性Castleman病伴副肿瘤性天疱疮的临床特征及外科治疗[J].中华医学杂志,2010,90(37):2657-2659. 被引量：6
  • 10刘洁,徐玉乔,杨守京.Castleman病的免疫表型和基因重排分析[J].临床与实验病理学杂志,2011,27(4):361-366. 被引量：24

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二级引证文献12

白血病．淋巴瘤
2013年 第12期

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