影响弥漫性轴索损伤预后因素分析及治疗

Analysis of the Influence of the Prognosis in Patients with DAI and its Treatment

目的研究弥漫性轴索损伤（diffuseaxonalin jury，DAI）患者相应观测指标对预后的影响，筛选出影响DAI预后的相关因素，为提高DAI的治疗水平提供临床依据。方法对121例DAI患者资料进行回顾性分析，研究预后与GCS评分、脑肿胀、瞳孔变化、蛛网膜下腔出血的相关性，脑肿胀患者进一步研究颅内压情况与预后关系，并进行相应治疗探讨。结果入院时GCS、瞳孔异常、脑肿胀情况与患者预后有关，脑肿胀患者颅内压增高程度与预后有关，蛛网膜下腔出血与预后无关。结论GCS越高、无瞳孔变化、无脑肿胀患者预后更好，脑肿胀引起颅内压增高的程度与预后负相关。

Objective To analyze the influence of corresponding clinical observations on the prognosis in patients with DAI,and to select the indices that can affect the prognosis to improve the therapeutic level of DAI patients.Method Clinical data of 121 DAI patients were retrospectively analyzed to identify the relationship between the indices and outcomes.Result The indices,including GCS,abnormal pupil,ICP and DBS were correlated with outcomes.Subarachnoid hemorrhage were not combined with therapeutic efficacy.Conclusion The patients with higher GCS,combined with none DBS,with abnormal pupil size and reaction,with light degree of ICP in DBS may have better outcome.