内质网应激与心肌缺血再灌注损伤的研究进展
被引量:2
摘要
缺血再灌注损伤(ischemic reperfusion injury)即当组织细胞低灌流缺血后获得血液重新供应时,不但未使组织细胞缺血性损害减轻或恢复,反而加重了缺血性损伤。内质网应激(endoplasmicreticulumstress,ERS)是指由于某些原因使得细胞中内质网的生理功能发生紊乱的一种亚细胞器病理过程,如蛋白质未折叠或错误折叠。缺血再灌注损伤可以引发内质网应激,而内质网应激过程中会激发细胞内很多信号通路,依照不同的情况一些会激发细胞的凋亡,另一些则会启动细胞自我挽救的保护机制;通过内质网应激引发细胞凋亡通路,很可能是心肌缺血再灌后引起心肌坏死损伤的原因之一。
出处
《中国血液流变学杂志》
CAS
2013年第3期586-588,共3页
Chinese Journal of Hemorheology
参考文献26
-
1Yellon DM,Hausenloy DJ. Myocardial reperfusion injury[J].{H}New England Journal of Medicine,2007,(11):1121-1135.
-
2Hausenloy DJ,Baxter G,Bell R. Translating novel strategies for cardioprotection:the Hatter Workshop Recommendations[J].{H}Basic Research in Cardiology,2010,(06):677-686.
-
3van Laake LW,Hassink R,Doevendans PA. Heart repair and stem cells[J].{H}JOURNAL OF PHYSIOLOGY,2006,(Pt 2):467-478.
-
4Boneberg EM,Hartung T. Molecular aspects of anti-inflammatory action of G-CSF[J].{H}Inflammation Research,2002,(03):119-128.
-
5Valgimigli M,Rigolin GM,Cittanti C. Use of granulocyte-colony stimulating factor during acute myocardial infarction to enhance bone marrow stem cell mobilization in humans:clinical and angiographic safety profile[J].{H}EUROPEAN HEART JOURNAL,2005,(18):1838-1845.
-
6Kuhlmann MT,Kirchhof P,Klocke R. G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis[J].{H}Journal of Experimental Medicine,2006,(01):87-97.
-
7Layton JE,Hall NE. The interaction of G-CSF with its receptor[J].{H}Frontiers in Bioscience,2006.3181-3189.
-
8Yeh ET,Zhang S,Wu HD. Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes,endothelial cells,and smooth muscle cells in vivo[J].{H}CIRCULATION,2003,(17):2070-2073.
-
9Iwanaga K,Takano H,Ohtsuka M. Effects of G-CSF on cardiac remodeling after acute myocardial infarction in swine[J].{H}Biochemical and Biophysical Research Communications,2004,(04):1353-1359.
-
10Nygren JM,Jovinge S,Breitbach M. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion,but not transdifferentiation[J].{H}Nature Medicine,2004,(05):494-501.
同被引文献24
-
1黎忠于,张黎辉,陈世洪,邓高峰,汤胜华.复方麝香注射液对心肌梗死大鼠心肌梗死面积的影响[J].湖北中医学院学报,2009,11(1):16-19. 被引量:4
-
2Forde RC, Fitzgerald DJ. Reactive oxygen species and platelet acti- vation in reperfusion injury [ J 1. Circulation, 1997, 95 (4) :787 - 789.
-
3Harold JG, Bass TA, Bashore TM, et al. Accf/aha/scai 2013 up- date of the clinical competence statement on coronary artery interven- tional procedures: A report of the american college of cardiology foundation/american heart association/american college of physicians task force on clinical competence and training (writing committee to revise the 2007 clinical competence statement on cardiac intervention- al procedures) [ J 1. Circulation, 2013, 128 (4) :436 - 472.
-
4Xu C, Bailly-Maitre B, Reed JC. Endoplasmic retieulum stress : Cell life and death decisions[ J]. J Clin Invest, 2005, 115(10) :2656 - 2664.
-
5Yang Y, Sun Y, Yi W, et al. A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clini- cal heart diseases[J]. J Pineal Res, 2014, 57(4) :357 -366.
-
6Yu L, Sun Y, Cheng L, et al. Melatonin receptor-mediated protec- tion against myocardial isehemia/reperfusion injury: Role of sirtl [J]. J Pineal Res, 2014, 57(2):228-238.
-
7Carloni S, Albertini MC, Galluzzi L, et al. Melatonin reduces endo- plasmic reticulum stress and preserves sirtuin 1 expression in neuro- nal cells of newborn rats after hypoxia-ischemia [ J ]. J Pineal Res, 2014, 57(2) :192 - 199.
-
8Kim SJ, Kang HS, Lee JH, et al. Melatonin ameliorates er stress- mediated hepatic steatosis through mir-23a in the liver[ J]. Biochem Biophys Res Commun, 2015, 458 (3) :462 - 469.
-
9San-Miguel B, Crespo I, Sanchez DI, et al. Melatonin inhibits auto- phagy and endoplasmie reticulum stress in mice with carbon tetrachlo- ride-induced fibrosis[ J]. J Pineal Res, 2015, 59 (2) : 151 - 162.
-
10Cruz MH, Leal CL, Cruz JF, et al. Essential actions of melatonin in protecting the ovary from oxidative damage [ J ]. Theriogenology, 2014, 82(7) :925 -932.
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-
7陈庆礼,刘全炯.麝香保心丸联合达格列净对HFrEF伴2型糖尿病患者的临床观察[J].北方药学,2023,20(10):140-143.
-
8张卫丰,马海龙,张金玲.橙皮素抑制TLR4-mTOR-ULK1信号通路对心肌缺血再灌注损伤大鼠细胞自噬和凋亡的影响[J].实用检验医师杂志,2024,16(2):133-138.
-
1杨波,张钧,许敬.心肌营养素-1和心血管疾病[J].心血管康复医学杂志,2004,13(3):302-304.
-
2贾玉杰,高静涛,姜妙娜,刘博,裴德恺.急性胰腺炎时胰腺细胞亚细胞器的功能变化及栀子的影响[J].大连医学院学报,1991,13(1):36-38. 被引量:6
-
3李云峰,于松杨,崔峰鹤,马圣君,孙学东.心肺运动试验在老年人术前评估中应用观察[J].健康大视野(医学版),2014,22(3):149-150.
-
4陆益龙,金蓉珍,王蓉芳.老年冠心病患者应激过程中血小板活性变化的观察[J].镇江医学院学报,1999,9(4):595-596. 被引量:4
-
5李学彦,林朝胜.老年缺血性肠病的新认识[J].中华老年心脑血管病杂志,2005,7(6):423-424. 被引量:14
-
6娄利霞,唐朝枢.内质网应激与心血管疾病[J].中国分子心脏病学杂志,2005,5(2):496-499. 被引量:19
-
7李雅琳,王启之.姜黄素在消化系统疾病治疗中的新进展[J].国际消化病杂志,2011,31(6):354-357.
-
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-
9王彩歌,王永霞.心肌缺血再灌注损伤的研究进展[J].世界中西医结合杂志,2012,7(8):734-736. 被引量:22
-
10屈腊元.中西医结合治疗稳定型心绞痛临床疗效观察[J].中西医结合心脑血管病杂志,2012,10(2):230-231. 被引量:7