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内质网应激与心肌缺血再灌注损伤的研究进展 被引量：2

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摘要 缺血再灌注损伤（ischemic reperfusion injury）即当组织细胞低灌流缺血后获得血液重新供应时，不但未使组织细胞缺血性损害减轻或恢复，反而加重了缺血性损伤。内质网应激（endoplasmicreticulumstress，ERS）是指由于某些原因使得细胞中内质网的生理功能发生紊乱的一种亚细胞器病理过程，如蛋白质未折叠或错误折叠。缺血再灌注损伤可以引发内质网应激，而内质网应激过程中会激发细胞内很多信号通路，依照不同的情况一些会激发细胞的凋亡，另一些则会启动细胞自我挽救的保护机制；通过内质网应激引发细胞凋亡通路，很可能是心肌缺血再灌后引起心肌坏死损伤的原因之一。
作者 郭小芙(综述) 杨向军(审校)
机构地区 苏州大学附属第一医院心内科 苏州市市立医院东区急诊科
出处 《中国血液流变学杂志》 CAS 2013年第3期586-588,共3页 Chinese Journal of Hemorheology
关键词 心肌缺血再灌注损伤 内质网应激 细胞凋亡 信号通路转导
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献26

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同被引文献24

  • 1黎忠于,张黎辉,陈世洪,邓高峰,汤胜华.复方麝香注射液对心肌梗死大鼠心肌梗死面积的影响[J].湖北中医学院学报,2009,11(1):16-19. 被引量：4
  • 2Forde RC, Fitzgerald DJ. Reactive oxygen species and platelet acti- vation in reperfusion injury [ J 1. Circulation, 1997, 95 (4) :787 - 789.
  • 3Harold JG, Bass TA, Bashore TM, et al. Accf/aha/scai 2013 up- date of the clinical competence statement on coronary artery interven- tional procedures: A report of the american college of cardiology foundation/american heart association/american college of physicians task force on clinical competence and training (writing committee to revise the 2007 clinical competence statement on cardiac intervention- al procedures) [ J 1. Circulation, 2013, 128 (4) :436 - 472.
  • 4Xu C, Bailly-Maitre B, Reed JC. Endoplasmic retieulum stress : Cell life and death decisions[ J]. J Clin Invest, 2005, 115(10) :2656 - 2664.
  • 5Yang Y, Sun Y, Yi W, et al. A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clini- cal heart diseases[J]. J Pineal Res, 2014, 57(4) :357 -366.
  • 6Yu L, Sun Y, Cheng L, et al. Melatonin receptor-mediated protec- tion against myocardial isehemia/reperfusion injury: Role of sirtl [J]. J Pineal Res, 2014, 57(2):228-238.
  • 7Carloni S, Albertini MC, Galluzzi L, et al. Melatonin reduces endo- plasmic reticulum stress and preserves sirtuin 1 expression in neuro- nal cells of newborn rats after hypoxia-ischemia [ J ]. J Pineal Res, 2014, 57(2) :192 - 199.
  • 8Kim SJ, Kang HS, Lee JH, et al. Melatonin ameliorates er stress- mediated hepatic steatosis through mir-23a in the liver[ J]. Biochem Biophys Res Commun, 2015, 458 (3) :462 - 469.
  • 9San-Miguel B, Crespo I, Sanchez DI, et al. Melatonin inhibits auto- phagy and endoplasmie reticulum stress in mice with carbon tetrachlo- ride-induced fibrosis[ J]. J Pineal Res, 2015, 59 (2) : 151 - 162.
  • 10Cruz MH, Leal CL, Cruz JF, et al. Essential actions of melatonin in protecting the ovary from oxidative damage [ J ]. Theriogenology, 2014, 82(7) :925 -932.

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中国血液流变学杂志
2013年 第3期

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