慢性乙型肝炎肝组织B7-1表达与α-干扰素近期疗效的关系

Relationship between the expression of B7-1 in liver tissue and the effect of interferon-alpha treatment in patients with chronic hepatitis B

目的 了解慢性乙型肝炎 (CHB)肝组织B7- 1表达与α -干扰素 (α -IFN)近期疗效的关系。方法 对 6 8例使用α -IFN的CHB患者治疗前行肝组织活检 ,采用免疫组织化学方法观察其B7- 1的表达。结果 6 8例CHB中 45例 (6 6 2 % )B7- 1表达阳性 ,5例正常人肝组织无表达。α -IFN的总应答率 ,肝组织B7- 1表达阳性组为 6 6 7% (30 /4 5 ) ,阴性组为 39 1% (9/2 3) ,二者差异显著 (χ2 =7 2 0 ,P <0 0 1)。随B7- 1阳性表达程度的增强 ,肝组织炎性活动积分 (HAI)及血清丙氨酸转氨酶 (ALT)异常值明显增加。结论 肝组织B7- 1表达水平可能是预测α -IFN近期疗效的重要参数之一。

Objectives To evaluate the relationship between the expression of B7-1 in liver tissue and the effect of interferon-alpha(α-IFN) treatment in patients with chronic hepatitis B(CHB).Methods The expression of B7-1 in liver biopsy specimens from 68 CHB patients was studied with immunohistochemistry before α-IFN treatment.Results B7-1 was expressed in 45(66 2%) liver tissues among 68 patients with CHB,but none in 5 normal controls.The total response ratio of α-IFN in patients with B7-1 positive was 66 7%(30/45),which was significantly higher than 39 1%(9/23)in the patients with B7-1 negative (χ 2=7 20,P<0 01).B7-1 expression was closely corelated with the histological activity grade(HAI) and serum alanine transaminase(ALT) level.Conclusions The level of B7-1 expression in liver tissue may be regarded as an effective parameter for predicting α-IFN response in patients with CHB.