挖空细胞在病理诊断尖锐湿疣中的诊断价值

Evaluation the pathological diagnostic values of koilocyte in condyloma acuminatum

目的 评价挖空细胞在组织学上诊断尖锐湿疣的诊断价值。方法 以挖空细胞作为诊断标准 ,对 2 0 6 3份活检标本进行组织学诊断 ,其诊断结果与病理学上诊断尖锐湿疣的“金标准”进行比较分析。结果 以挖空细胞作为尖锐湿疣的组织学诊断标准 ,其诊断的灵敏度为 77.93 % ,特异度95 .2 6 % ,阳性预告值 97.2 5 % ,阴性预告值 6 6 .70 % ,阳性似然比 81.81,阴性似然比 2 3.17,漏诊率2 2 .0 7% ,误诊率 4.74%。结论 挖空细胞是细胞感染人乳头瘤病毒 (HPV)或其他病毒后 ,在形态学上发生特异性改变 ,是诊断尖锐湿疣的重要组织学依据 。

Objective To evaluate the histological diagnostic values of koilocyte in histopathologic diagnosis of condyloma acumunatum.Methods Koilocyte was served as diagnostic criteria to scan 2 063 biopsies and compared the results with “goldan standard” of histopathologic diagnosis of condyloma acuminatum. Results Using koilocyte as diagnostic standard to diagnose condlyma acuminatum, the sensitivity and specificity were 77.93 % and 95.26 %, with positive predictive value 97.25 %, negative predictive value 66.70 %, positive likelihood rate 81.81 ,negative likelihood rate 23.17 , under diagnostic rate 22.07 %, misdiagnostic rate 4.74 %. Conclusion The koilocyte was proved to be one of classical histopathological morphologic features of human papillomavirus infection and other virus infection which served one of the most importent histopathological markers for diagnosis of condyloma acuminatum,but not the only one.