经皮二尖瓣球囊扩张成形术前后血栓素及前列环素水平的变化

Change of the thromboxane and prostacyclin level before and after percutaneous balloon mitral valvuloplasty

对 5 1例成功实现经皮二尖瓣球囊扩张成形术 (PBMV)的患者 ,于术前、术后分别测定血栓素 (TXB2 )及 6 -酮前列环素 F1α(6 - K- PGF1α) ,并与 30例正常人作对照。测得数值与二尖瓣口面积 (MVA)、左房内径 (L AD) ,二尖瓣跨瓣压差 (MVPG)、心脏指数 (CI)、平均左房压 (ML AP)及右室收缩压 (RVSP)进行相关分析。结果表明 :PBMV前 TXB2 高于对照组 ,6 - K- PGF1α低于对照组 (P<0 .0 5 ) ;PBMV后 TXB2 较术前降低 ,6 - K- PGF1α增高 (P<0 .0 1) ;TXB2 与 MVA呈负相关 (r=- 0 .48,P<0 .0 5 )。提示 PBMV后 TXB2 、6 - K- PGF1α水平的变化与 MVA大小、ML AP高低密切相关。

Thromobixane(TXB 2)and prostacyclin(6 K PGF 1α )were measured in 51 patients with percutaneous balloon mitral valvuloplasty(PBMV)before and after the procedure respectively,and 30 volunteers as normal control group The data was carried out for relationship analysis with area of mitral valve(MVA),left artral diameter(LAD),average transmural pressure of mitral valve(MVPG),cardial index(CI),mean left artrial pressure(MLAP) and right ventricular systolic pressure(RVSP).The result showed TXB 2 was higher and 6 K PGF 1α was lower than the control before PBMV(P<0 05),TXB 2 decreased and 6 K PGF 1α increased after PBMV(P<0 01) TXB 2 and MVA have a negtively association(r=-0 48,P<0 05).These suggest that changes of TXB 2 and 6 K PGF 1α levels after PBMV have a significant association with MVA and MLAP