孤立性脑型毛霉菌病1例报告并文献复习

Isolated cerebral mucormycosis(a report of 1 case and review of literature)

目的探讨脑型毛霉菌病的临床特征及诊治方法,以提高对本病的认识。方法报告1例孤立性脑型毛霉菌病治愈病例的临床资料,并结合文献探讨该病的临床特点和诊断治疗方法。结果患者病灶位于右侧基底节区,经立体定向穿刺取活检进行涂片及病理检查,确诊为毛霉菌病。同时合并梗阻性脑积水,病灶予以置管引流,并行侧脑室腹腔分流、神经内镜治疗脑积水,以两性霉素B药物治疗,临床治愈。结论早期诊断,足量足疗程使用两性霉素B,并进行正确外科干预,是提高脑型毛霉菌病治愈率的有效方法。

Objective To explore the charactristics, diagnosis and treatment of cerebral mucormycosis. Methods The linical of one patient with isolated cerebral mucormyeosis was reported and the charactristics, diagnosis and treatment were discussed with literature reviewed. Results The abscess was located in the right basal ganglia. A biopsy was made and mucormycosis was diagnosed by smear and pathology. A drainage tube was placed in the abscess and the secondary hydrocephalus was treated by a ventriculoperitoneal shunt and neuroendoscopy. Intravenous Amphotericin B was applied and the clinical result was good. Conclusion Prompt diagnosis,application of enough Amphoteriein B and correct surgical intervention are the effective methods of improving the cure rate of cerebral mucormycosis.