替吉奥联合三维适形放疗对胰腺癌细胞生物学的影响

Effect of S-1 Combined with Three-dimensional Conformal Radiotherapy on Biological Behavior of Pancreatic Cancer Cells

目的:探究替吉奥复方制剂联合三维适形放射疗法对胰腺癌细胞生物学的影响及安全性评价。方法:培养PANC-1人胰腺癌细胞,构建PANC-1胰腺癌裸鼠异位肿瘤模型并随机进行分组。观察替吉奥联合三维适形放疗对胰腺癌肿瘤细胞生长的抑制作用,记录荷瘤裸鼠的肿瘤体积以及生存期。同时观察联合治疗所产生的副作用。结果:相比于单独用药组和单独放疗组,联合组能够显著抑制肿瘤体积生长,延长荷瘤裸鼠的中位生存期。结论:替吉奥单独给药和单独三维适形放疗均能抑制肿瘤的生长,二者联合使用能够发挥协同作用,是一种潜在的高效的胰腺癌治疗手段。

Objective： To estimate the effect of S-1 combined with three-dimensional conformal radiotherapy on the biological be- haviour of pancreatic cancer cells. Methods： PANC-1 cells were cultured and xenografted in athymic nude mice to establish the animal model, which were used to evaluate the effect of anti-pancreatic cancer. In addition, we evaluated the side effect of the combined treat- ment. Results： The combination of S-1 and three-dimensional conformal radiotherapy can prolong the median survival time of PANC-1 bearing nude mice than other groups significantly. Conclusion： The combination of S-1 and three-dimensional conformal radiotherapy may be a potentially effective treatment for pancreatic cancer with the advantages of inhibiting the growth of pancreatic cancer.