IgA肾病预后的相关影响因素分析

Risk Factors Related to the Pognosis of IgA Nphropathy

目的:分析IgA肾病预后的相关影响因素,为IgA肾病的治疗提供可靠的依据。方法:选择我市三家医院经病理确诊的143例IgA肾病患者,记录其临床资料,根据随访结果将患者的预后分为优、良、中、差4个档次,通过单因素、多因素等方法获得IgA肾病预后的影响因素。结果:1.LEE氏病理组织学分级是IgA肾病患者预后的危险因素,分级越高预后越差,P<0.01。2.单因素分析:年龄、病程、高血压、尿蛋白含量、水肿程度、肉眼血尿均为其危险因素,ACEI治疗为其保护因素,P<0.01。3.多因素分析显示尿蛋白含量、LEE肾组织学分级、病程、高血压及ACEI治疗纳入的累计概率模型有统计学意义。结论:尿蛋白含量、LEE肾组织学分级、病程、高血压是IgA肾病预后的危险因素,ACEI治疗是其保护因素。

Objective： To analyze the risk factors related to the prognosis of IgA nephropathy, and to provide a reliable basis for the treatment oflgA nephropathy. Methods： 143 cases of patients with IgA nephropathy diagnosed by three hospitals in our city were se- lected and divided into excellent, good, fair and poor according to the results of the prognosis. The IgA nephropathy prognosis factors were achieved by single factor and multi-factors analyses. Results： 1. LEE＇s histological grade is the risk factor for prognosis of patients with IgA nephropathy, and the higher grade will lead the worse prognosis, P〈0.01.2. Univariate analysis： age, duration, high blood pres- sure, urine protein content, the edema degree and gross hematuria are the risk factors for prognosis of patients with IgA nephropathy, and ACEI treatment is a protection factor for prognosis of patients with IgA nephropathy, P 〈0.01.3. Multivariate analysis showed that uri- nary protein content, Lee renal histological grade, duration, hypertension and ACEI treatment in cumulative probability model were sta- tistically significant. Conclusion： Urinary protein content, Lee renal histological grade, duration, hypertension were risk factors for the prognosis of IgA nephropathy, and ACEI therapy is a protective factor.