miR-155与胶质瘤的研究进展

Research Progress on miR-155 and Glioma

人脑胶质瘤是最常见的原发性脑肿瘤,起源于脑部神经胶质细胞,约占所有颅内肿瘤的45%左右,在儿童恶性肿瘤中排第二位。胶质瘤系浸润性生长物,它和正常脑组织没有明显界限,难以完全切除,对放疗化疗不甚敏感,非常容易复发,且手术难以切除或根本不能手术。化学药物和一般抗肿瘤的中药,因血脑屏障等因素的影响,疗效也不理想,因此脑胶质瘤至今仍是全身肿瘤中预后最差的肿瘤之一。人类miR-155是由位于21号染色体的BIC基因外显子3编码的多功能miRNA,在干细胞分化、免疫、炎症、癌症、心血管疾病以及病毒感染的病理生理过程中发挥重要作用,也是联系炎症和癌症的桥梁。miR-155在人胶质瘤中作用机制的研究才刚刚起步,目前miR-155与人胶质瘤的关系的研究已成为研究热点。人胶质瘤中miR-155及其相关调控机制的研究,将更有利于人胶质瘤的早期诊断和基因治疗的发展。本文就miR-155与胶质瘤的研究进展予以综述。

Glioma that originated in the brain glial cells is the most common primary brain tumor, about 45% of all intracranial tumors, which ranks second in children with malignant tumors. Glioma is infiltrative growing neoplasms and has no obvious boundaries with the normal brain tissue, which is difficult to complete resection. Glioma is not sensitive to chemotherapy and radiotherapy, very easy to relapse and difficult to cut out or not operate.The effect of chemical drugs and anti-tumor medicine, due to the impact of the blood brain barrier factors, is not ideal, Therefore, glioma is still one of the worst prognosis of tumor in body tumors. Human miR-155 is composed of BIC gene which is located on chromosome 21 in exon multifunctional miRNA 3 code and play an important role in the pathophysiological process of differentiation of stem cells, immune, inflammation, cancer, cardiovascular disease and virus infection.lt is also a bridge to link to inflammation and cancer. Study on the mechanism of action of miR-155 in gliomas has just started, the research on the relationship between miR-155 and human glioma has become a research hotspot. Research on human miR-155 glioma and its regulatory mechanism, development will be more conducive to the early diagnosis and gene therapy of human glioma. In this paper, the research progress ofmiR - 155 and glioma shall be reviewed.