慢性氟中毒大鼠大脑皮质NOS阳性神经元的变化

Changes of nitric oxide synthase positive neurons in the rat cerebral cortex with fluorosis

目的 探讨慢性氟中毒对大鼠大脑皮质一氧化氮合酶 (NOS)阳性神经元的影响。方法 采用NADPH-黄递酶 (NADPH- d)组织化学方法 ,标记大脑皮质 NOS阳性神经元 ,对慢性氟中毒大鼠大脑皮质 NOS阳性神经元变化进行计数。结果 慢性氟中毒大鼠皮质 NOS阳性神经元数明显少于对照组 (P <0 .0 1)。结论 慢性氟中毒大鼠脑内皮质 NOS阳性神经元的改变可能是氟中毒影响脑功能的重要原因之一。

Objective To investigate the changes of nitric oxide synthase positive neurons in the rat cerebral cortex with Fluorosis.Methods NADPH d histochemistry method was used to study the change of nitric oxide synthase (NOS) neurons in chronic fluorsis rat cerebral cortex was significantly decreased as compared with the control.Results The positive neurons in chronic fluorosis rat cerebral cortex were much less than those in the control.Conclusions It is concluded that the chronic fluorosis could effect the number of NOS positive neurons and may be effect the study and memory of brain.