丹红注射液治疗老年慢性肺源性心脏病急性加重疗效观察

Curative Observation of Danhong Injection on Treating Aged Acute Exacerbated Geriatric Chronic Pulmonary Heart Disease

目的:观察丹红注射液治疗老年慢性肺源性心脏病急性加重的临床疗效。方法:将80例慢性肺源性心脏病患者按就诊顺序随机分为治疗组和对照组,各40例。两组患者均予以积极控制感染,解痉平喘、祛痰,纠正缺氧及二氧化碳潴留、酸碱失衡和电解质紊乱,常规抗右心衰治疗。观察组在对照组治疗基础上加用丹红注射液30ml加入5%葡萄糖或生理盐水250m冲静脉点滴,每日1次,14日为1疗程。比较治疗前后总体疗效及血气分析、心功能、肺动脉压力、肺功能的变化。结果:治疗组的总体疗效优于对照组,两组之间血气分析、心功能、肺动脉压力、肺功能比较均有统计学意义(P<0.05)。结论:丹红注射液对慢性肺源性心脏病急性加重有较好疗效。

Objective： This paper aimed to observe the clinical effect of Danhong injection on acute exacerbated geriatric chronic pulmonary heart disease. Methods： 80 chronic pulmonary heart disease cases were divided into treatment group （40 ca- ses） and controlled group （40 cases） randomly according to their registration order. Both of these two groups were treated with active infection control, spasmolysis and asthma relieving, eliminating phlegm, correcting hypoxemia and carbon dioxide reten- tion, acid-base imbalance as well as electrolyte disturbance, and conventional resistance to right heart failure. On the basis of the controlled group, the treatment group received additional 30 ml Danhong Injection with 5% glucose or 250ml normal saline through vein infusion once every day, 14 days for a course of treatment. The overall curative effect, blood gas analysis, heart function, pulmonary artery pressure and lung function variation were compared before and after the treatment. Results ： The over- all curative effect of treatment group was better than that of the controlled group. The comparison of blood gas analysis, heart function, pulmonary artery pressure and lung function between these two groups had statistical significance （ P 〈 0. 05）. Con- clusion： Danhong injection has good curative effect on acute exacerbated geriatric chronic pulmonary heart disease.