加味止颤汤治疗帕金森病睡眠障碍的临床观察

Clinical Observation of Using JIawei Zhichan Decoction to Treat Sleep Disorders in Parkinson Disease

目的:了解加味止颤汤对帕金森患者睡眠障碍的疗效。方法:选取帕金森睡眠障碍患者60例,在原来治疗基础上加用中药加味止颤汤治疗,2周后逐渐将原西药按个体需量减量,在患者治疗前和治疗后三个月分别予帕金森病睡眠量表(PDSS)、嗜睡量表(ESS)、汉密尔顿抑郁评价量表(HAMD)进行评估。用两均数差别的显著性检验(t检验)评价疗效。结果:治疗前后比较,帕金森病睡眠量表(PDSS)、Epworth嗜睡量表(ESS)评分有非常显著的差异(P<0.001);汉密尔顿抑郁评价量表(HAMD)评分,也有显著差异(P<0.01)。结论:中药加味止颤汤对帕金森患者的睡眠障碍及白天嗜睡状况有改善作用,再加用心理疏导治疗,对帕金森患者的抑郁状况亦有改善。

Objective： To observe the therapeutic effect of Jiawei Zhichan Decoction on improving sleep disorders in patients with Parkinson Disease. Methods ： The experiment selected 60 cases of Parkinson patients with sleep disorders and then added the Jiawei Zhichan Decoction into the original therapy. Two weeks later, the western medicine were decreased gradually according to the patients. Evaluated the patients before the therapy and three months after the therapy based on the PDSS, ESS and HAMD. Tested the therapeutic effect with T test. Results： In experiment, PDSS and ESS had highly significant differences before and af- ter treatment （P 〈 0. 001 ）, HAMD had significant differences before and after treatment （P 〈 0. 01 ）. Conclusions： The ex- periment indicates that the Jiawei Zhichan Decoction can improve the sleep disorders and the hypersomnia in the daytime of the Parkinson Patient. And the decoction can also improve the depression of the Parkinson Patient with psychology induction addition- ally.