不同浓度肝素钠疏通深静脉导管完全堵塞的疗效观察

The efficacy of different concentrations of heparin to clear deep venous catheter completely blocked

目的探讨应用不同浓度的肝素钠疏通患者深静脉导管完全堵塞的疗效。方法对近3年来化疗患者深静脉导管完全堵塞分别采用浓度为30U/ml、60U/ml、90U/ml和120U/ml肝素钠溶液进行溶解疏通,并记录导管再通率、再通时间和并发症情况。结果 30U/ml、60U/ml、90U/ml和120U/ml 4种肝素钠溶液再通率分别为57.5%、72.5%、87.5%和92.5%,总再通率为77.5%,4种浓度再通率差异有统计学意义(P<0.05);4种浓度的平均再通时间差异无统计学意义(P>0.05);未发生与使用肝素钠有关的并发症。结论对化疗患者堵塞的深静脉导管及时应用肝素钠溶液可安全有效地恢复导管的通畅。

Objective To investigate the efficacy of different concentrations of heparin to clear deep venous catheter com- pletely blocked. Methods Chemotherapy in patients, with deep venous catheter completely blocked in the past three years in our hospital, were treated with different concentrations of 30U/ml 60u/ml, 90U/mL, and 120U/mL heparin solution dissolved to dredge and recorded the catheter recanalization rate, time and concurrency recanalization diseases. Results The heparin solution recanalization rate of 30U/ml 60u/ml 90U/ml and 120U/ml respectively was 57.5% , 72.5% , 87.5% and 92.5% , total reca- nalization rate was 77.5%, the differences of four concentrations of recanalization rate were statistically significant （ P 〈 0.05 ）, the differences of four concentrations of the average recanalization time were not statistically significant（ P 〉 0. 05 ）, and it did not occur with the sodium heparin-related complications. Conclusion Chemotherapy in patients with deep venous catheter blockage, timely application of heparin solution could be safe and effective in restoring patency of the catheter.