2013例教职工肿瘤标志物阳性率及相关因素分析

An analysis of correlation factors of the positive rate of serum tumor markers in 2013 staff

目的了解肿瘤标志物阳性者在体检人群中的分布,对影响肿瘤标志物阳性率的相关因素进行分析。方法对2013名参加体检的教职工的体检资料进行研究分析,多元logistic回归分析肿瘤标志物阳性率的相关因素。结果2013名体检人群中筛选出阳性率最高的四项肿瘤标志物分别是CA199(1.54%)、CEA(0.99%)、CA125(0.55%)、CA242(0.40%),其中CEA、CA125的阳性率在不同性别间有差异(P<0.05)。ALT、年龄是CA199的独立因素;年龄、GLU是CEA的危险因素;DBIL、UA、年龄是肿瘤标志物CA125的相关因素(P<0.05)。结论血清肿瘤标志物在健康人群中有一定的阳性率,定期体检对于肿瘤的早期发现具有重要价值。

Objective To investigate the distribution of the serum tumor markers positive in health examination people, to analyze the correlation factors of positive rate of these serum tumor markers . Methods 2013 health human clinical data were col- lected and analyzed the influencing factors by multiple regression. Results Among the 2013 subjects, the positive rate of CA199, CEA,CA125,CA242 were 1.54%, 0.99%, 0.55%, 0.40% respectively. The positive rate of CEA and CA125 in femal group was higher than that in the male group. Multiple regression suggested that age, alanine transaminase were influencing factors onthe result of CA199 （P 〈 0.05 ） ;the positive of CEA was affected by age and blood glucose（ P 〈 0.05 ） ;the levels of blood bilirubin, uric acid, age were significantly correlated with the positive rate of CA125 （P 〈 0.05 ）. Conclusion The positive rate of serum tumor biomarkers in some health examination peoples was higher. The periodic health examination would be important for early diagnostic of cancer.