孟鲁司特联合舒利迭治疗对哮喘患者气道高反应性的影响

Montelukast combined with seretide in the treatment of patients with asthma airway hyper responsiveness

目的探讨孟鲁司特联合舒利迭治疗对支气管哮喘患者气道高反应性的影响。方法 57例支气管哮喘非急性发作期患者,随机分为治疗组30例和对照组27例。两组均予以解痉、平喘、止咳、祛痰等常规综合治疗,治疗组在常规治疗基础上加用舒利迭吸入及孟鲁司特咀嚼片,总疗程3个月,观察疗效,并测定第0、1、3个月的肺功能。结果治疗组治疗后的肺功能和PC_(35)sGaw浓度与对照组比较,差异有统计学意义,P<0.05。结论孟鲁司特联合舒利迭治疗支气管哮喘,能明显增强患者的肺功能,进一步降低气道高反应性。

Objective Montelukast combined with seretide in the treatment of patients with asthma airway hyper respon- siveness. Methods 57 cases of patients with acute exacerbation of bronchial asthma, were randomly divided into the treatment group of 30 patients and the control group of 27 cases. The two groups were to be antispasmodic, asthma, cough, phlegm and other conventional treatment, the treatment group plused Seretide inhalation and montelukast chewable tablets, total course was 3months. Curative effect, and determination of zeroth month, first month, third months of pulmonary function were observated. Results Lung function and PC35sGaw concentration had statistically significant difference, P 〈 0.05. Conclusion Montelukast combined with seretide in the treatment of bronchial asthma, could obviously improve the pulmonary function, and reduce the air- way hyper responsiveness.