高血压患者靶器官损害与动态血压参数研究

Research on target organs damage and ambulatory blood pressure monitoring parameters of hypertensive patients

目的探讨高血压患者动态血压参数与其靶器官损害的关系。方法收集符合纳入标准高血压患者动态血压监测等资料,分为单纯高血压组(n=18)和高血压伴靶器官损害组(n=79),比较2组间及靶器官损害组内的动态血压参数。结果靶器官损害组的年龄及病程大于单纯高血压组(P<0.05);伴3个靶器官损害组病程、24h SBP、24h DBPV大于伴1个靶器官损害组(P<0.05)。多因素分析显示,病程、24h SBP及24h DBPV与高血压患者靶器官受损量有相关关系。结论病程、24h SBP、24h DBPV是高血压患者靶器官损害及程度重要判断指标。

Objective To explore the relationship of the ambulatory blood pressure monitoring parameters and target or- gan damages of hypertensive patients. Methods The datas of the hypertensive patients＇ ambulatory blood pressure monitoring （ABPM） were collected and divided into the isolated hypertension group（ n = 18） and the hypertensive organs damaged group （ n = 79）. The ABPM parameters between the two groups and among the organs damaged group were valuated with statistic meth- ods. Results The age and disease progression of hypertensive organs damaged group were greater than the hypertensive group （ P 〈 0. 05 ） ;the disease progression, 24h SBP, 24h DBPV of the patients with 3 target organs damage were greater than those of ones with 1 target organ damage（ P 〈 0. 05 ）. Multivariate analysis showed there were relationship between the disease progression, 24h SBP, 24h DBPV and the damage of target organs of hypertensive patients. Conclusion The disease progression, 24h SBP and 24h DBPV would be important indicators for hypertensive target organs damage and their extent.