低剂量环孢A联合糖皮质激素治疗难治性自身免疫性血小板减少症的疗效观察

Low dose cyclosporin A combined with glucocorticoid inthe treatment of refractory autoimmune thrombocytopenia.

目的研究低剂量环孢素A联合糖皮质激素治疗难治性血小板减少症的临床疗效。方法选择30例难治性自身免疫性血小板减少症患者,随机分为两组,每组15例,一组给予低剂量环抱A联合糖皮质激素口服,一组给予标准剂量糖皮质激素口服,每周复查血小板计数,对比血小板上升情况。结果口服环孢A联合糖皮质激素组2周内血小板计数明显上升,显性出血明显改善,激素减量后患者血小板计数无明显下降。单用糖皮质激素组在药物减量过程中短期内血小板计数明显下降,显性出血风险明显增加。体重增加,血糖升高等不良反应明显比环孢A组高。结论低剂量环孢A联合糖皮质激素治疗难治性自身免疫性血小板减少症有确切疗效,不良反应少,值得推广。

Objective Study on the use of low dose of cyclosporine A combined with glucocorticoid in the treatment of re- fractory autoimmune thrombocytopenia. Methods 30 cases of refractory autoimmune thrombocytopenia patients, were randomly divided into two groups, 15 patients in each group, one group was treated with low dose A combined with glucocorticoid, the other group were given a standard dose of glucocorticoid oral weekly review. The platelet count were compared. Results Cyclosporin A combined with giucocorticoid group, platelet count was significantly increased after 2 weeks, the single glucocorticoid group in drug reduction in platelet count decreased significantly in the short term, the dominant hemorrhage increased risk. Conclusion Low dose cyclosporin A combined with glucocorticoid in the treatment of refractory autoimmune thrombocytopenia had exact cura- tive effect, it would be worth popularizing.