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依托咪酯对大鼠脑缺血再灌注损伤的保护作用及其机制 被引量：2

Protective effects of etomidate against global brain ischemia-reperfusion injury in SD rats
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摘要 目的探讨依托咪酯对大鼠脑缺血再灌注损伤的保护作用及其机制。方法 SD大鼠60只,随机分为对照组(S)、缺血再灌注组(IR)和依托咪酯组(Etom),各20只。采用4-VO法建立大鼠全脑缺血再灌注模型。缺血再灌注后1d、3d、7d用免疫组化法测定海马CA1区神经元mPTP的表达。结果与S组相比,IR组和Etomidate组海马CA1区神经元mPTP的表达明显上升(P<0.01),但Etom组海马CA1区神经元mPTP的表达低于IR组(P<0.05)。组内各时间点表达水平差异无统计学意义(P>0.05)。结论依托咪酯对大鼠脑缺血再灌注损伤有一定的保护作用,可能是通过抑制mPTP的表达而发挥作用的。 Objective To investigate the protective effects and possible mechanisms of Et0midate against global brain is. chemia-reperfusion injury in SD rats. Methods Twenty-seven SD rats were randomly divided into three groups： sham operation group（S） ; IR group and Etomidate（Etom） group. Global brain ischemic model was established by 4-VO method. The expression of mPTP was determined by immunochemistry the 1 st day, 3th day, 7 th day after global brain ischemia-reperfusion injury. Results Compared with sham group, the expression of mPTP was significantly increased in IR group and Etom-group （P 〈 0. 01 ） ; but the expression of mPTP in Etom-group than IR group. Conclusion Peritonael injection of Etomidate before ischemia could protect the brain against IR injury in SD rats through an inhibition of mPTP expression.
作者 侯俊 杨鹏 汤和青 皮明芳 方为 冯雪刚
机构地区 三峡大学第一临床医学院 湖北省宜昌市中心医院麻醉科
出处 《四川医学》 CAS 2013年第12期1795-1797,共3页 Sichuan Medical Journal
关键词 依托咪酯 海马 mPTP 缺血再灌注损伤 etomidate hippocampus mPTP ischemia-reperfusion injury
分类号 R965 [医药卫生—药理学]
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参考文献8

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二级参考文献35

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同被引文献14

  • 1Herregods LL, Bossuyt GP, De Baerdemaeker LE,et al. Ambulatory electrical external eardioversion with propofol or etomidate [ J ]. J Clin Anesth ,2003,15 ( 2 ) :91 - 96.
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  • 7李宁江,沈立红,袁春晖,高恩付.不同麻醉诱导气管插管对危重患者心血管应激反应的影响[J].广东医学,2010,31(1):98-99. 被引量：24
  • 8宣慧仁,封飚,贺兴义.依托咪酯乳剂用于高龄危重患者全身麻醉诱导的临床观察[J].实用医技杂志,2010,17(9):867-867. 被引量：8
  • 9陈秀辉.丙泊酚在急诊脑外伤气管插管中的临床应用[J].浙江创伤外科,2010,15(5):690-691. 被引量：3
  • 10聂祥碧,王曾庚,郭经华,杨小刚,曾卫华.ICU选择性气管插管前镇静的临床应用分析[J].中国医药导报,2010,7(33):166-167. 被引量：6

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二级引证文献15

四川医学
2013年 第12期

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