透明质酸钠联合盐酸氨基葡萄糖治疗老年颞下颌关节紊乱病

Observation on the efficacy of sodium hyaluronate combined with glucosamine hydrochloride for aged patients with temporomandibular disorder

目的观察透明质酸钠、盐酸氨基葡萄糖治疗颞下颌关节紊乱病(TMD)的临床疗效。方法对收治的32例老年TMD患者,予透明质酸钠1ml关节上腔注射,1次/周,同时口服盐酸氨基葡萄糖胶囊750mg,2次/d,治疗时间为5周,并对治疗前、后颞下颌关节(TMJ)疼痛程度和开口度进行临床疗效评价。结果 31例患者TMJ疼痛、开口度均明显缓解或改善(P<0.05),总有效率96.88%。结论透明质酸钠联合盐酸氨基葡萄糖治疗老年TMD,能明显缓解关节疼痛,改善关节活动度,值得临床推广运用。

Objective To observe the efficacy of sodium hyaluronate combined with glucosamine hydrochloride for aged patients with temporomandibular disorder. Methods 32 aged patients with TMD were treated with injection of sodium hyaluronate 1 ml into the upper compartment of TMJ each week, and oralling glucosamine hydrochloride capsule 750 mg twice every day. The progress was 5 weeks. The paindegree of TMJ and the mouth opening degree were observed. Results The pain degree of TMJ and the mouth opening degree of 31 patients were significantly alleviated and improved （ P 〈 0. 05 ）. The total effective rate was 96. 88% ： Conclusion Sodium hyaluronate combined with glucosamine hydrochloride in the treatment of aged patients with TMD could alleviate the pain of TMD and improve the activity of TMJ. It might be wortl＇I popularizing in the clinical practice.