摘要
综述了魔芋胶、海藻酸钠和果胶等多糖改性,作为口服结肠靶向给药系统载体材料的应用进展。其改性后疏水性提高、溶胀度降低,在胃肠道下端缓慢溶胀、到达结肠部位释药。最后展望了改性多糖类化合物的发展趋势。
The application progress of konjac glucomannan,sodium alginate and pectin,etc.,as drug carrier in the oral colon-specific drug delivery system are summarized.After being modified,their hydrophobic increase and swelling degree decrease,and they can swell slowly on the lower end of the gastrointestinal tract and release the drug in the colon.And their development trends are discussed.
基金
国家自然科学基金(20864001
31160326)
广西科学研究与技术开发项目(桂科能10100025)
广西研究生教育创新计划项目资助
关键词
改性多糖
结肠靶向
给药载体
modified polysaccharides
colon-targeting
drug delivery carrier
