紫杉醇联合顺铂同步调强放射治疗局部晚期食管癌的疗效观察

目的评价紫衫醇联合顺铂化疗同步调强放射治疗（IMRT）局部晚期食管癌的临床疗效及安全性。方法局部晚期食管癌患者88例随机均分为治疗组和对照组，其中治疗组45例，采用紫衫醇联合顺铂；对照组43例，采用5-氟尿嘧啶联合顺铂，两组均采用IMRT。比较两组的近期疗效、生存率以及不良反应。结果治疗组和对照组的有效率分别为88．9％和76．7％，差异有统计学意义（P〈0．05）。治疗组1，2年总生存率分别为80．1％和46.5％，而对照组1，2年总生存率为71.3％和39.3％，差异有统计学意义（P〈0．05）。结论紫杉醇联合氟尿嘧啶同步调强放射治疗局部晚期食管癌有较好的疗效和安全性。

Objective To explore the effect and security of docetaxel plus cisplatin chemotherapy with concurrent intensity-modu- lated radiotherapy（IMRT） for locally advanced esophageal cancer.Methods All 88 patients with locally advanced esophageal can- cer were divided randomly into the treatment group and the control group.Treatment group with 46 eases were treated with doc- etaxel and cisplatin,and control group with 42 cases were treated with 5-FU and cisplatin.Both groups patients received IMRT. The recent clinical effect,overall survival time and side effects were observed and compared.Results The effective rate in the treatment group and the control group were 88.9% and 76.7% individually,which were significantly higher than that of control group （P 〈 0.05）.1-2 year survival rate in treatment group were 80.1% and 46.5% and control group was 71.3% and 39.3% re- spectively,with a statistical significance （P 〈 0.05）.Conclusion Paclitaxel combined with fluorouracil concurrent IMRT for locally advanced esophageal has better efficacy and less adverse react ions.