140例亚临床甲减对冠心病相关危险因素的影响

Effect of 140 cases of subclinical hypothyroidism on coronary heart disease risk factor

目的 探讨亚临床甲减对冠心病相关危险因素的影响,为采用抗甲减措施抑制冠心病提供依据.方法 选取本院2011年2月~2012年2月收治并行冠状动脉造影术（CAG）患者140例,以诊断出冠心病患者作为冠心病组,其余为对照组,监测游离T3、游离T4、促甲状腺素、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白Al、载脂蛋白B,诊断亚临床甲减、高血压、糖尿病、高血脂,进行因素分析.结果 冠心病组与对照组合并高血压、高血脂、糖尿病差异无统计学意义（P＞0.05）;亚临床甲减与高血压、高血脂存在相关性,亚临床甲减与冠心病存在相关性（OR=2.236,P=0.015）;经过多因素分析,亚临床甲减、高血压、TG、HDL与冠心病高度相关.结论 亚临床甲减与冠心病存在正相关,与冠心病相关危险因素存在关联,直接或间接成为冠心病的危险因素,加强对甲减的监控,有利于疾病的防治.

Objective To explore the effect of subclinical hypothyroidism on coronary heart disease risk factors, as the anti hypothyroidism measures to provide the basis for the inhibition of coronary heart disease. Methods From February 2011 to February 2012 who underwent coronary angiography （CAG） in 140 patients with coronary heart disease patients, diagnosed as CHD group, the other as the control group, monitoring of free T3, free T4, thyroid stimulating hormone, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A1, apolipoprotein B, diagnosis of subclinical hypothyroidism, hypertension, diabetes, high blood lipids, factor analysis. Results The coronary heart disease group and the control group and hypertension, hyperlipidemia, diabetes were not statistically significant （ P 〉 0.05 ） ; there is the relationship between subclinical hypothyroidism and hypertension, high blood fat, the correlation of subclinical hypothyroidism with coronary heart disease （OR = 2. 236, P = 0.015 ） ; after multivariate analysis, subclinical hypothyroidism, hypertension, TG, HDL and coronary heart disease was highly related to. Conclusion There is a positive correlation of subclinical hypothyroidism with coronary heart disease, is associated with coronary heart disease risk factors, directly or indirectly, as a risk factor for coronary heart disease, strengthen the monitoring of hypothyroidism, is beneficial to the prevention and treatment of disease.