生命早期饥荒暴露对50岁成年人血脂、血糖水平的影响

The effect of the famine exposure in early life of the 50-year-old adult on the levels of blood fat and blood glucose

目的：检测饥荒年出生人群50岁时总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白、空腹血糖水平,探讨生命早期营养对成人疾病的影响.方法：2011年从安徽省某大型三级甲等医院健康体检中心整群抽取出生于1957~1963年的体检者4理214名.按出生时间将研究对象分为3组,1957~1958年出生的982人为饥荒前暴露组;1959~1961年出生的1 233人为饥荒暴露组;1962~1963年出生的1 999人为饥荒后暴露组.比较组间空腹低密度脂蛋白、高密度脂蛋白、三酰甘油、总胆固醇和空腹血糖水平的差异及变化趋势.结果：不同年份出生的体检者总胆固醇、三酰甘油、低密度脂蛋白和高密度脂蛋白差异均有统计学意义（P〈0.05~P〈0.01）,而空腹血糖差异无统计学意义（P〉0.05）.饥荒前暴露组男性三酰甘油低于饥荒后暴露组（P〈0.01）.女性空腹血糖、总胆固醇和低密度脂蛋白水平饥荒前暴露组均高于饥荒暴露组和饥荒后暴露组（P〈0.05~P〈0.01）.结论：生命早期饥荒暴露可能对成年后血糖、血脂代谢产生影响,这种影响对50岁以上男女的影响可能更为显著.孕期女性合理膳食、均衡营养对从根源上预防子代成年后慢性代谢性疾病意义深远.

Objective ：To detect the levels of total cholesterol, triacylglycerol, low-density lipoprotein（ LDL）, high-density lipoprotein （HDL） and fasting blood glucose in 50 years old crowd with early life exposure to famine, and explore the influence of early life nutrition on adult diseases. Methods：Four thousand two hundred and fourteen adults born in 1957 - 1963 from a hospital physical examination center in 2011 in Anhui were divided into exposure before famine group （982 cases born in 1957 to 1958 ）, exposure famine group（1 233 cases born in 1959 to 1961 ） and exposure after famine group（ 1 999 cases born in 1962 to 1963）. The levels of total cholesterol,triacylglycerol, LDL, HDL and fasting blood glucose in three groups were compared. Results：Except the fasting blood glucose level, the differences of the levels of total cholesterol, triacylglycerol, LDL and HDL in different cases had statistical significance （ P 〈 0.05 to P 〈 0. 01 ）. The level of male triacylglycerol in exposure before famine group was lower than that in exposure after famine group（P 〈0.01 ）. The levels of female fasting blood glucose, total cholesterol and LDL in exposure before famine group were higher than those in exposure famine group and exposure after famine group （P 〈 0. 05 to P 〈 0.01 ）. Conclusions：The early life malnutrition maybe influence the metabolism of blood fat and blood glucose after adult, which may be more remarkable in male with more than 50 years old. The reasonable nutrition in pregnant women has far-reaching significance in preventing chronic metabolic disease in their offspring.